Cambinol

Dangerous Goods

CAS number：14513-15-6 molecular formula：C21H16N2O2S

overview

Specs

numbering system

physicochemical properties

Safety information

Production methods and uses

MSDS

overview

compound introduction

Cambinol 是一种 SIRT1 和 SIRT2 的抑制剂，IC50 值分别为 56 μM 和 59 μM。Cambinol 是中性鞘磷脂酶 (N-SMase) 的抑制剂(外泌体抑制剂)。 application： Cambinol has been used: as an inhibitor of sirutins (SIRT1 and 2) in hepatocarcinoma cell lines to test its effect on cellular viability and colony formation as a SIRT1 and SIRT2 inhibitor to test its effect on frizzled 7 (FZD7) expression in the breast cancer cells MDA-MB-231 and T-47D cells as a sirutin inhibitor in L929 cells to test its protective effect against tumor necrosis factor (TNF)-induced cell death. Biochemical mechanism: Cambinol is a Sirtuin (Human Silent Information Regulator) Type 1/2 Inhibitor. Sirtuins are structurally and mechanistically unrelated to HDACs Class 1 & 2 deacetylases but share many protein targets. HDAC is a large complex enzyme family involved in epigenetic-control of gene expression. Sirt2 has an IC50 equal to 59 μM. Cambinol, a β-naphthol compound, elicits antitumor activity and impairs the mitogen-activated protein kinase (MAPK) signaling. It has ability to inhibit the secretion of inflammatory cytokines including the tumor necrosis factor and interleukins. Cambinol can be a potential therapeutic agent for treating inflammatory diseases. It also aids protection in events of endotoxic and septic shock.

Specs

Chinese alias	5-[(2-羟基-1-萘基)甲基]-2-巯基-6-苯基-4 (3H)-嘧啶酮, NSC-1125476, 5-(2-羟基萘-1-基甲基)-6-苯基-2-硫代-2,3-二氢-1H-嘧啶-4-酮, 四氢-5-[(2-羟基-1-萘基)甲基]-6-苯基-2-硫代-4 (1H)-嘧啶酮 \| 甘比诺
English alias	SCHEMBL2538372 \| SIRT1/2 Inhibitor IV, Cambinol \| BDBM29040 \| C3535 \| A858236 \| SIRT 1/2 inhibitor IV; NSC112546; NSC-112546; NSC 112546; SIRT1 Inhibitor II; SIRT2 Inhibitor VI \| SIRT1/2 Inhibitor IV \| 2,3-Dihydro-5-((2-hydroxy-1-naphthalenyl)methyl)-6-ph
CAS number	14513-15-6	molecular formula	C21H16N2O2S
molecular weight	360.43 g/mol	Exact mass	10mM in DMSO
PSA	93.500 Å²	logp	4.100

numbering system

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Safety information

pictogram：

GHS07

Signal word：

Warning

Hazard Statement：

H319: 引起严重眼睛刺激 H302: 吞食有害

Statement of Preventive Measures：

P305+P351+P338: 如进入眼睛：用水小心冲洗几分钟。如戴隐形眼镜并可方便地取出，取出隐形眼镜。继续冲洗。 P280: 戴防护手套/穿防护服/戴防护眼罩/戴防护面具。 P501: 将内容物/容器处理到。。。 P264: 处理后要彻底洗手。 P270: 使用本产品时，请勿进食、饮水或吸烟。 P330: 漱口 P264+P265: 处理后彻底洗手[和…]。不要触摸眼睛。 P301+P317: 如果被吞咽：请寻求医疗帮助。 P337+P317: 如果眼睛刺激持续：寻求医疗帮助。