compound introduction
Monomethyl auristatin E (MMAE, SGD-1010)与单克隆抗体(MAB)有关。它也是一种能够破坏微管的试剂.
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MonoMethyl auristatin E
Dangerous GoodsCAS number：474645-27-7 molecular formula：C39H67N5O7
overview
Specs
| Chinese alias | - | ||
| English alias | L-Valinamide, N-methyl-L-valyl-N-((1S,2R)-4-((2S)-2-((1R,2R)-3-(((1R,2S)-2-hydroxy-1- methyl-2-phenylethyl)amino)-1-methoxy-2-methyl-3-oxopropyl)-1-pyrrolidinyl)-2- methoxy-1-((1S)-1-methylpropyl)-4-oxobutyl)-N-methyl- | Monomethyl auristatin E (MMAE) | D | ||
| CAS number | 474645-27-7 | molecular formula | C39H67N5O7 |
| molecular weight | 717.98 g/mol | Exact mass | 10mM in DMSO |
| PSA | 150.000 Ų | logp | 4.100 |
numbering system
No numbering system information yet
physicochemical properties
No physical and chemical property information yet
Safety information
pictogram：
GHS06 , GHS08 , GHS07
Signal word：
Danger
Hazard Statement：
H315: 引起皮肤刺激 H319: 引起严重眼睛刺激 H335: 可能引起呼吸道刺激 H341: 怀疑引起遗传缺陷 H302: 吞食有害 H300: 吞咽致命 H330: 吸入致命 H372: 通过长时间或反复暴露对器官造成损害 H360: 可能损害生育力或未出生的孩子 H370: 对器官造成损害
Statement of Preventive Measures：
P261: 避免吸入灰尘/烟雾/气体/雾/蒸汽/喷雾 P305+P351+P338: 如进入眼睛：用水小心冲洗几分钟。如戴隐形眼镜并可方便地取出，取出隐形眼镜。继续冲洗。 P280: 戴防护手套/穿防护服/戴防护眼罩/戴防护面具。 P302+P352: 如皮肤沾染：用水充分清洗。 P321: 特殊处理（请参阅此标签上的...）。 P405: 密闭存放 P501: 将内容物/容器处理到。。。 P264: 处理后要彻底洗手。 P260: 不要吸入灰尘/烟雾/气体/雾/蒸汽/喷雾。 P284: 如果通风不良，请
Production methods and uses
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Related
upstream information
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downstream information
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MSDS
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