CAS number：423148-78-1 molecular formula：C14H7ClFN3O5
PYZD-4409 是 ubiquitin-activating enzyme UBA1 的特异性抑制剂，其 IC50 值为 20 μM。PYZD-4409 能诱导恶性细胞死亡，并优先抑制原发性急性髓性白血病细胞的生长。 Product description PYZD-4409 is a specific inhibitor of the ubiquitin-activating enzyme UBA1 with an IC50 of 20 μM (cell-free enzymatic assay). PYZD-4409 induces cell death in malignant cells and preferentially inhibits the clonogenic growth of primary acute myeloid leukemia cells.
| Chinese alias | 1-(3-氯-4-氟苯基)-4-[(5-硝基-2-呋喃基)亚甲基] -3,5-吡唑烷二酮 | ||
| English alias | A913455 | PYZD-4409 | (E)-1-(3-chloro-4-fluorophenyl)-4-((5-nitrofuran-2-yl)methylene)pyrazolidine-3,5-dione | 1-(3-Chloro-4-fluorophenyl)-4-[(5-nitro-2-furanyl)methylene]-3,5-pyrazolidinedione | (Z)-1-(3-chloro-4-fluorophenyl)-4-((5-nitrofuran-2-yl)methy | ||
| CAS number | 423148-78-1 | molecular formula | C14H7ClFN3O5 |
| molecular weight | 351.67 g/mol | Exact mass | ≥98%(HPLC) |
| PSA | 108.000 Ų | logp | 2.800 |
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