AFMK是松果激素褪黑激素的代谢产物，具有抗氧化，免疫调节和抗炎特性。首先在大鼠大脑中检测到AFMK，发现AFMK可用作褪黑激素合成和代谢的指标。 应用： AFMK 是褪黑激素的一种抗氧化代谢物，可减弱 X 射线诱导的小鼠 DNA、蛋白质和脂质氧化损伤。AFMK 是效果稍低的一种清洁剂，在生理 pH 值下的 pKa 为 8.7。具有抗氧化活性。AFMK 可通过调节细胞凋亡途径提高 Gemcitabine 在 PANC-1 细胞中的抗肿瘤作用。 AFMK is a metabolite of the pineal hormone melatonin that exhibits antioxidant, immunomodulatory and anti-inflammatory properties. AFMK was first detected in rat brain and was found to be useful as an index for melatonin synthesis and metabolism. Application： AFMK, antioxidant metabolite of Melatonin, attenuates X-ray-induced oxidative damage to DNA, proteins and lipids in mice. AFMK is a poorer scavenger. The pKa of AFMK at physiological pH is 8.7. Antioxidant capacity. AFMK improves the anti-tumor effect of Gemcitabine in PANC-1 cells through the modulation of apoptotic pathway.
All
Chemical Reagents
Biomedicine
Organic raw materials
Inorganic chemical industry
intermediate
Agricultural chemicals
Auxiliaries and catalysts
Fragrances and Flavors
Dyes and Pigments
Daily chemical industry
AFMK
Dangerous GoodsCAS number：52450-38-1 molecular formula：C13H16N2O4
overview
compound introduction
Specs
| Chinese alias | - | ||
| English alias | Acetyl-N-formyl-5-methoxykynurenamine | NCGC00165716-01 | FT-0661243 | AKOS030240039 | SCHEMBL63260 | AFMK | N-?-Acetyl-N-2-formyl-5-methoxykynurenamine | A-Acetyl-N-2-formyl-5-methoxykynurenamine | AB12510 | N-[3-(2-formamido-5-methoxy-phenyl)-3-oxo-prop | ||
| CAS number | 52450-38-1 | molecular formula | C13H16N2O4 |
| molecular weight | 264.28 g/mol | Exact mass | - |
| PSA | 84.500 Ų | logp | 0.600 |
numbering system
No numbering system information yet
physicochemical properties
No physical and chemical property information yet
Safety information
pictogram：
GHS06
Signal word：
Danger
Hazard Statement：
H301: 吞咽会中毒
Statement of Preventive Measures：
P321: 特殊处理（请参阅此标签上的...）。 P405: 密闭存放 P501: 将内容物/容器处理到。。。 P264: 处理后要彻底洗手。 P270: 使用本产品时，请勿进食、饮水或吸烟。 P330: 漱口 P301+P316: 如果吞咽：立即寻求紧急医疗救助。
WGK Germany：
3
Production methods and uses
No production method and use information yet
Related
upstream information
No upstream information yet
downstream information
No downstream information yet
MSDS
Found 0 shareMSDS
