compound introduction
Apstatin是一种氨肽酶P（APP）的选择性抑制剂，大鼠肺膜结合APP中的K | i |为2.6μM。Apstatin已显示可通过抑制APP的缓激肽降解作用来增强人工诱发的心肌梗死大鼠的缓激肽促进的心脏保护作用。当与血管紧张素转换酶抑制剂依那普利，赖诺普利或雷米普利组合使用时，心肌梗死面积的减少会增加。 Apstatin is a selective inhibitor of aminopeptidase P (APP), with a K|i|of 2.6 μM in rat lung membrane-bound APP. Apstatin is shown to increase Bradykinin-promoted cardioprotection in rats with artificially introduced myocardial infarctions by inhibiting the Bradykinin degradation action of APP. When combined with the angiotensin-converting enzyme inhibitors enalapril , lisinopril , or ramipril , decrease of myocardial infarction size was enhanced.
