compound introduction
依那普利特-d5钠盐是依那普利的标记代谢产物。依那普利是一种血管紧张素转换酶（ACE）抑制剂，被认为比卡托普利更有效。据报道该化合物通过肝水解转化为活性形式恩那普利拉。研究表明，依那普利下调IL-β，IL-6和NF-κB的表达。进一步的研究表明，依那普利上调VEGF和血红素加氧酶-1的表达。 Enalaprilat-d5 Sodium Salt is a labeled metabolite of Enalapril. Enalapril is a angiotensin-converting enzyme (ACE) inhibitor, suggested to be more potent than Captopril . The compound is reported to be converted to the active form, Enalaprilat , through hepatic hydrolysis. Studies indicate that Enalapril downregulates the expression of IL-beta, IL-6, and NF-kappaB. Further studies show that Enalapril upregulates the expression of VEGF and heme oxygenase-1.
