Vidofludimus

Dangerous Goods

CAS number：717824-30-1 molecular formula：C20H18FNO4

overview

Specs

numbering system

physicochemical properties

Safety information

Production methods and uses

MSDS

overview

compound introduction

Vidofludimus (SC12267, 4SC-101) 是一种口服具有活性的，有效的dihydroorotate dehydrogenase (DHODH)抑制剂，对人DHODH的IC50为134 nM。Vidofludimus calcium (IMU-838)正作为COVID-19的潜在治疗选择研究中。Phase 2 Information Vidofludimus Vidofludimus (SC12267, 4SC-101) is an orally active and potent dihydroorotate dehydrogenase (DHODH) inhibitor with IC50 of 134 nM for human DHODH. Vidofludimus calcium (IMU-838) is investigated as a potential treatment option for COVID-19. Phase 2. Targets Human DHODH 134 nM In vitro Vidofludimus causes a concentration dependent inhibition of phytohemagglutinin-stimulated PBMC proliferation via the inhibition of pyrimidine de novo synthesis. Vidofludimus attenuates IL-17 secretion from colonic strips by inhibition of STAT3 and NF-κB activation. In vivo In MRL lpr/lpr mice, Vidofludimus (300 mg/kg, p.o.) reduces systemic autoimmunity and improves Lupus Nephritis. In Rats, Vidofludimus (60 mg/kg, p.o.) effectively reduces macroscopic and histological pathology and the numbers of CD3+ T cells. In a rat model of renal transplantation, Vidofludimus (20 mg/kg, p.o.) prolongs survival, paralleled by amelioration of histologic signs of acute rejection. Cell Research(from reference) Cell lines：PBMCs Incubation Time：48 h

Specs

Chinese alias	维多弗迪莫斯
English alias	EX-A4148 \| s7262 \| (+/-) ethylnipecotate \| 2,2'-Anhydro(1.beta.-D-arabinofuranosyl)uracil \| NCGC00246751-01 \| NCGC00345056-01 \| 4SC-101 \| 4sc-101;SC12267 \| A866371 \| BCP14555 \| AC-32911 \| Vidofludimus \| 2-((3-Fluoro-3'-methoxy-[1,1'-biphenyl]-4-yl)carbamo
CAS number	717824-30-1	molecular formula	C20H18FNO4
molecular weight	355.36 g/mol	Exact mass	-
PSA	75.600 Å²	logp	3.878

numbering system

No numbering system information yet

physicochemical properties

No physical and chemical property information yet

Safety information

pictogram：

GHS08 , GHS07

Signal word：

Danger

Hazard Statement：

H413: 可能对水生生物造成长期的有害影响 H302: 吞食有害 H360: 可能损害生育力或未出生的孩子

Statement of Preventive Measures：

P273: 避免释放到环境中。 P280: 戴防护手套/穿防护服/戴防护眼罩/戴防护面具。 P405: 密闭存放 P501: 将内容物/容器处理到。。。 P264: 处理后要彻底洗手。 P201: 使用前获取特殊说明 P308+P313: 如接触到或有疑虑：求医/就诊。 P270: 使用本产品时，请勿进食、饮水或吸烟。 P202: 在阅读并理解所有安全预防措施之前，不要进行操作。 P330: 漱口 P301+P312: 如误吞咽：如感觉不适，呼叫急救中心/医生。