Molidustat (BAY 85-3934)

Dangerous Goods

CAS number：1154028-82-6 molecular formula：C13H14N8O2

overview

Specs

numbering system

physicochemical properties

Safety information

Production methods and uses

MSDS

overview

compound introduction

Information Molidustat (BAY 85-3934) Molidustat (BAY 85-3934) is a potent hypoxia-inducible factor prolyl hydroxylase ( HIF-PH ) inhibitor with IC50 of 480 nM, 280 nM, and 450 nM for PHD1, PHD2, and PHD, respectively. Phase 2. Targets PHD2 (Cell-free assay); PHD3 (Cell-free assay); PHD1 (Cell-free assay) 280 nM; 450 nM; 480 nM In vitro Molidustat induces the transcription of hypoxia-sensitive genes in HeLa, A549, and Hep3B cells. In vivo In healthy Wistar rats and cynomolgus monkeys, Molidustat (1.5 mg/kg, p.o.) induces dose-dependent production of EPO and erythropoiesis. In rats with gentamicin-induced renal anemiabe, Molidustat (5 mg/kg, p.o.) is also effective in raising hematocrit levels while stimulating endogenous EPO production without hypertensive effects.

Specs

Chinese alias	莫司他 (BAY 85-3934)
English alias	3H-Pyrazol-3-one, 1,2-dihydro-2-[6-(4-morpholinyl)-4-pyrimidinyl]-4-(1H-1,2,3-triazol-1-yl)- \| Molidustat(BAY 85-3934) \| NCGC00388364-04 \| UNII-9JH486CZ13 \| 2-(6-Morpholin-4-Ylpyrimidin-4-Yl)-4-(1,2,3-Triazol-1-Yl)-1~{h}-Pyrazol-3-One \| BCP14477 \| DTXSID8
CAS number	1154028-82-6	molecular formula	C13H14N8O2
molecular weight	314.3 g/mol	Exact mass	-
PSA	101.000 Å²	logp	-0.2

numbering system

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Safety information

pictogram：

GHS08 , GHS07

Signal word：

Danger

Hazard Statement：

H302: 吞食有害 H372: 通过长时间或反复暴露对器官造成损害 H360: 可能损害生育力或未出生的孩子

Statement of Preventive Measures：

P280: 戴防护手套/穿防护服/戴防护眼罩/戴防护面具。 P405: 密闭存放 P501: 将内容物/容器处理到。。。 P264: 处理后要彻底洗手。 P260: 不要吸入灰尘/烟雾/气体/雾/蒸汽/喷雾。 P270: 使用本产品时，请勿进食、饮水或吸烟。 P330: 漱口 P203: 使用前，获取、阅读并遵守所有安全说明。 P301+P317: 如果被吞咽：请寻求医疗帮助。 P318: 如果暴露或担心，请就医。 P319: 如果你感到不适，请寻求医疗帮助。