N-Nornuciferine

Dangerous Goods

CAS number：4846-19-9 molecular formula：C18H19NO2

overview

Specs

numbering system

physicochemical properties

Safety information

Production methods and uses

MSDS

overview

compound introduction

N-Nornuciferine is an aporphine alkaloid in lotus leaf that significantly inhibits CYP2D6 with IC 50 and K i of 3.76 and 2.34 μM, respectively. In Vitro The herb of lotus leaves is a commonly used traditional Chinese medicine with a wide range of pharmacological and physiological activities, particularly the reduction of the blood triglyceride and cholesterol levels. N-Nornuciferine strongly inhibits CYP2D6 activity but shows weak or no inhibition of the other four P450 isoenzymes (CYP2C19, CYP3A4, CYP2E1, CYP2C9). N-Nornuciferine competitively inhibits the CYP2D6-catalyzed dextromethorphan o-demethylation with apparent K i values of 2.34 μM. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid IC50& Target:CYP2

Specs

Chinese alias	N-去甲荷叶碱
English alias	4H-Dibenzo[de,g]quinoline, 5,6,6a,7-tetrahydro-1,2-dimethoxy-, (R)- \| N-Nornuciferine \| 6a.beta.-Noraporphine, 1,2-dimethoxy- \| 1,2-Dimethoxynoraporphine \| (R)-5,6,6a,7-Tetrahydro-1,2-dimethoxy-4H-dibenzo[de,g]quinoline \| 1,2-Dimethoxy-6a.beta.-noraporphi
CAS number	4846-19-9	molecular formula	C18H19NO2
molecular weight	281.3 g/mol	Exact mass	≥99%
PSA	30.500 Å²	logp	3.000

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Safety information

pictogram：

GHS06

Signal word：

Danger

Hazard Statement：

H301: 吞咽会中毒 H311: 皮肤接触有毒 H331: 吸入会中毒

Statement of Preventive Measures：

P261: 避免吸入灰尘/烟雾/气体/雾/蒸汽/喷雾 P280: 戴防护手套/穿防护服/戴防护眼罩/戴防护面具。 P302+P352: 如皮肤沾染：用水充分清洗。 P321: 特殊处理（请参阅此标签上的...）。 P405: 密闭存放 P501: 将内容物/容器处理到。。。 P264: 处理后要彻底洗手。 P271: 仅在室外或通风良好的地方使用。 P270: 使用本产品时，请勿进食、饮水或吸烟。 P304+P340: 如误吸入：将人转移到空气新鲜处，保持呼吸舒适体位。 P403+P233: 存放在通风良