Information TRx0237 (LMTX) mesylate TRx 0237 mesylate (LMTX, Hydromethylthionine) is a second-generation tau protein aggregation inhibitor for the treatment of Alzheimer's disease (AD) and frontotemporal dementia. Targets tau protein aggregation In vitro TRx 0237 (LMTX™) is a second-generation tau protein aggregation inhibitor for the treatment of Alzheimer\'s disease (AD) and frontotemporal dementia. It is a purified forms of Methylene Blue, an old drug that predates the FDA and is being widely used in Africa for the treatment for malaria as well as for methemoglobinemia and other conditions. An in vitro study showed the ability of TRx 0237 in disrupting PHFs(paired helical filaments) isolated from Alzheimer\'s Disease brain tissues at the concentration at 0.16 μM. In vivo TRx 0237 dose-dependently rescues the learning impairment and restores behavioral flexibility in a spatial problem-solving water-maze task in L1 (minimum effective dose: 9 mg MT/kg for TRx0237) and correctes motor learning in L66 (effective doses: 4 mg MT/kg). It reduces the number of tau-reactive neurons, particularly in the hippocampus and entorhinal cortex in L1 and in a more widespread manner in L66.
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TRx0237 (LMTX) mesylate
Dangerous GoodsCAS number：1236208-20-0 molecular formula：C18H27N3O6S3
overview
compound introduction
Specs
| Chinese alias | - | ||
| English alias | TRx0237 mesylate;Methylene blue leuco base mesylate | LEUCO-METHYLTHIONINIUM BIS(HYDROMETHANESULFONATE) | Leucomethylene blue Mesylate | N3,N3,N7,N7-Tetramethyl-10H-phenothiazine-3,7-diaminedimethanesulfonate | MS-28864 | Leucomethylene blue (Mesylate) | | ||
| CAS number | 1236208-20-0 | molecular formula | C18H27N3O6S3 |
| molecular weight | 477.62 g/mol | Exact mass | 10mM in DMSO |
| PSA | 169.000 Ų | logp | - |
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Safety information
pictogram：
GHS07
Signal word：
Warning
Hazard Statement：
H315: 引起皮肤刺激 H319: 引起严重眼睛刺激 H335: 可能引起呼吸道刺激 H302: 吞食有害
Statement of Preventive Measures：
P261: 避免吸入灰尘/烟雾/气体/雾/蒸汽/喷雾 P305+P351+P338: 如进入眼睛：用水小心冲洗几分钟。如戴隐形眼镜并可方便地取出，取出隐形眼镜。继续冲洗。 P280: 戴防护手套/穿防护服/戴防护眼罩/戴防护面具。 P302+P352: 如皮肤沾染：用水充分清洗。 P321: 特殊处理（请参阅此标签上的...）。 P405: 密闭存放 P501: 将内容物/容器处理到。。。 P264: 处理后要彻底洗手。 P271: 仅在室外或通风良好的地方使用。 P270: 使用本产品时，请勿进食、饮水
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