Tabersonine hydrochloride

Dangerous Goods

CAS number：29479-00-3 molecular formula：C21H24N2O2.HCl

overview

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physicochemical properties

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MSDS

overview

compound introduction

Tabersonine hydrochloride 是一种主要从蔷薇中分离出的吲哚类生物碱。Tabersonine 能破坏 Aβ(1-42) 的聚合和改善 Aβ 聚集诱导的细胞毒性。Tabersonine hydrochloride 具有抗炎活性，可用于 ALI/ARDS 的研究。 Information Tabersonine hydrochloride Tabersonine, an ingredient extracted from the bean of Voacanga africana, is a potent inhibitor against Aβ(1−42) aggregation and toxicity. Targets Aβ(1−42) aggregation In vitro Tabersonine disrupts Aβ(1−42) aggregation and ameliorates Aβ aggregate-induced cytotoxicity. It binds to Aβ(1−42) oligomers more strongly than to Aβ(1−42) monomers with Kd values of 69 μM and 535 μM, respectively. In vivo The biocompatibility and small size essential for permeating the blood−brain barrier make tabersonine a potential therapeutic drug candidate for treating Alzheimer\'s disease (AD). Cell Research(from reference) Cell lines：SH-SY5Y cell Concentrations：10 μM Incubation Time：24 h

Specs

Chinese alias	-
English alias	Tabersonine monohydrochloride \| E74579 \| HY-N1431A \| UNII-DGR7D6J5TR \| Aspidospermidine-3-carboxylic acid, 2,3,6,7-tetradehydro-, methyl ester, monohydrochloride, (5.alpha.,12.beta.,19.alpha.)- \| TabersonineHydrochloride \| Aspidospermidine-3-carboxylic ac
CAS number	29479-00-3	molecular formula	C21H24N2O2.HCl
molecular weight	372.89 g/mol	Exact mass	10mM in DMSO
PSA	41.600 Å²	logp	-

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Safety information

pictogram：

GHS07

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Warning

Hazard Statement：

H302: 吞食有害 H332: 吸入有害

Statement of Preventive Measures：

P261: 避免吸入灰尘/烟雾/气体/雾/蒸汽/喷雾 P501: 将内容物/容器处理到。。。 P264: 处理后要彻底洗手。 P271: 仅在室外或通风良好的地方使用。 P270: 使用本产品时，请勿进食、饮水或吸烟。 P304+P340: 如误吸入：将人转移到空气新鲜处，保持呼吸舒适体位。 P330: 漱口 P301+P317: 如果被吞咽：请寻求医疗帮助。 P317: 寻求紧急医疗救助。