compound introduction
Umeclidinium bromide是一种长效毒蕈碱拮抗剂，对治疗慢性阻塞性肺疾病具有持续性疗效。 Information Umeclidinium bromide is a long-acting muscarinic antagonist approved for the maintenance treatment of chronic obstructive pulmonary disease (COPD). Targets mAChR In vitro Umeclidinium is a novel mAChR antagonist. The affinity (Ki) of Umeclidinium for the cloned human M1-M5 mAChRs ranged from 0.05 to 0.16 nM. In vivo Umeclidinium is a potent anticholinergic agent that demonstrates slow functional reversibility at the human M3 mAChR and long duration of action in animal models.
