compound introduction
PB 28 dihydrochloride 是一种高亲和力选择性σ2受体活化剂（对于σ2和σ1受体，K | i |值分别为0.8和15.2 nM），对其他受体的亲和力最小。PB 28二盐酸盐抑制豚鼠膀胱和回肠的电诱发抽搐（EC | 50 |值分别为2.62和3.96μM）。PB 28二盐酸盐在SK-N-SH神经母细胞瘤和C6胶质瘤细胞中也显示出抗增殖和细胞毒性作用。 PB 28 dihydrochloride is a high affinity selective σ2 receptor Activators (K|i|values are 0.8 and 15.2 nM for σ2 and σ1 receptors respectively) that displays minimal affinity at other receptors. PB 28 dihydrochloride inhibits electrically evoked twitch in guinea pig bladder and ileum (EC|50|values are 2.62 and 3.96 μM respectively). PB 28 dihydrochloride also displays antiproliferative and cytotoxic effects in SK-N-SH neuroblastoma and C6 glioma cells.
