Information PF 429242 PF 429242 is known as a S1P inhibitor with an IC50 of 170 nM, showing no significant inhibition of trypsin, elastase, proteinase K, plasmin, kallikren, factor XIa, thrombin, or furin at concentrations up to 100 μM and only modest inhibition of urokinase (IC50 = 50 μM) and factor Xa (IC50 = 100 μM). Targets S1P (Cell-free assay) 170 nM In vitro In cultured human liver (Hep-G2) cells, PF-429242 prevents proteolytic processing and nuclear translocation of SREBP, reduces the expression of key genes involved in cholesterol synthesis and fatty acid synthesis, and inhibits both pathways in the absence of any cytotoxicity. The addition of PF-429242 suppresses the viral propagation of all serotypes of DENV in several primate-derived cells. In vivo PK data for PF-429242 show that it had rapid clearance (CL = 75 ml/min/kg) and poor oral bioavailability (5%) in rats. Cell Research(from reference) Cell lines：HeLa cells Concentrations：3 to 300 µM Incubation Time：72 h
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PF 429242
Dangerous GoodsCAS number：947303-87-9 molecular formula：C25H35N3O2
overview
compound introduction
Specs
| Chinese alias | - | ||
| English alias | PF-429242 dihydrochloride | (R)-4-((Diethylamino)methyl)-N-(2-methoxyphenethyl)-N-(pyrrolidin-3-yl)benz amide | AKOS015998619 | HY-13447 | Q27259314 | NCGC00387092-02 | NCGC00387092-01 | NCGC00387092-03 | Benzamide, 4-((diethylamino)methyl)-N-(2-(2-methox | ||
| CAS number | 947303-87-9 | molecular formula | C25H35N3O2 |
| molecular weight | 409.58 g/mol | Exact mass | 10mM in DMSO |
| PSA | 44.800 Ų | logp | 3.600 |
numbering system
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physicochemical properties
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Safety information
pictogram：
GHS09 , GHS07
Signal word：
Warning
Hazard Statement：
H315: 引起皮肤刺激 H319: 引起严重眼睛刺激 H335: 可能引起呼吸道刺激 H400: 对水生生物有剧毒
Statement of Preventive Measures：
P261: 避免吸入灰尘/烟雾/气体/雾/蒸汽/喷雾 P305+P351+P338: 如进入眼睛：用水小心冲洗几分钟。如戴隐形眼镜并可方便地取出，取出隐形眼镜。继续冲洗。 P273: 避免释放到环境中。 P280: 戴防护手套/穿防护服/戴防护眼罩/戴防护面具。 P302+P352: 如皮肤沾染：用水充分清洗。 P321: 特殊处理（请参阅此标签上的...）。 P405: 密闭存放 P501: 将内容物/容器处理到。。。 P264: 处理后要彻底洗手。 P271: 仅在室外或通风良好的地方使用。 P304
Production methods and uses
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Related
upstream information
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downstream information
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MSDS
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