T807 a novel tau positron emission tomography (PET) tracer. In Vitro Aggregated tau protein is a major neuropathological substrate central to the pathophysiology of neurodegenerative diseases such as Alzheimer's disease (AD). In vitro autoradiography results show that [ 18 F]T807 exhibits strong binding to PHF-tau positive human brain sections (K d =14.6 nM). A comparison of autoradiography and double immunohistochemical staining of PHF-tau and Ab on adjacent sections demonstrates that [ 18 F]T807 binding colocalizes with immunoreactive PHF-tau pathology, but does not highlight Ab plaques. [ 18 F]T807 strongly binds to tau lesions primarily made of paired helical filaments in Alzheimer’s brains e.g. intra and extraneuronal tangles and dystrophic neurites. [ 18 F]T807 off-target binding to neuromelanin- and melanin-containing cells and, to a lesser extent, to brain hemorrhagic lesions is identified. MCE has not independently confirmed the accuracy of these methods. They are for reference only. In Vivo [ 18 F]T807 is able to cross the blood–brain barrier and ished out quickly in mice model. [ 18 F]T807 clears rapidly from the brain, with activity values decreasing from 4.43% ID/g at 5 minutes to 0.62% ID/g at 30 minutes. Kidney elimination is a significant clearance pathway, resulting in a maximum tracer concentration of 14.99% ID/g in the kidneys at 5 minutes, which decreases to 5.52% ID/g at 30 minutes. The accumulation of activity in muscle and bone remain relatively low throughout the PET scan . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid
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T807
Dangerous GoodsCAS number：1415379-56-4 molecular formula：C16H10FN3
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| Chinese alias | 7-(6-氟吡啶-3-基)-5H-吡啶并[4,3-b]吲哚 | ||
| English alias | Flortaucipir (F-18) | J09QS3Z3WB | A910886 | 7-(6-fluoropyridin-3-yl)-5h-pyrido[4,3-b]indole | 7-(6-Fluoro-3-pyridinyl)-5H-pyrido[4,3-b]indole | 1415379-56-4 | AV1451 | AV-1451AV-1451 | BS-15380 | C72630 | 5H-Pyrido(4,3-b)indole, 7-(6-fluoro-3-pyridinyl)- | ||
| CAS number | 1415379-56-4 | molecular formula | C16H10FN3 |
| molecular weight | 263.27 g/mol | Exact mass | - |
| PSA | 41.600 Ų | logp | 3.300 |
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physicochemical properties
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Safety information
pictogram：
GHS07
Signal word：
Warning
Hazard Statement：
H319: 引起严重眼睛刺激
Statement of Preventive Measures：
P305+P351+P338: 如进入眼睛：用水小心冲洗几分钟。如戴隐形眼镜并可方便地取出，取出隐形眼镜。继续冲洗。 P280: 戴防护手套/穿防护服/戴防护眼罩/戴防护面具。 P264+P265: 处理后彻底洗手[和…]。不要触摸眼睛。 P337+P317: 如果眼睛刺激持续：寻求医疗帮助。
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