TP0427736是一种有效的ALK5 kinase抑制剂，IC50为2.72 nM，对ALK3的IC50为836 nM。在A549细胞中，它还能抑制TGF-β1诱导的Smad2/3磷酸化，IC50为8.68 nM。 Information TP0427736 is a potent inhibitor ofALK5 kinase activitywith anIC50of 2.72 nM and this effect is 300-fold higher than the inhibitory effect on ALK3 (IC50 = 836 nM for ALK3). It also inhibits Smad2/3 phosphorylation in A549 cells induced by TGF-β1 with an IC50 value of 8.68 nM. Targets ALK5 (Cell-free assay) 2.72 nM In vitro TP0427736 inhibits Smad2/3 phosphorylation in a concentration-dependent manner, with an IC50 value of 8.68 nM. In a cell-based assay of outer root sheath cells, TP0427736 rescued the inhibited proliferation by TGF-β1 and TGF-β2 in a concentration-dependent manner. In vivo TP0427736 decreases shortening of hair follicle length during the transition from the late anagen phase to the catagen phase. Cell Research(from reference) Cell lines：A549 cells Incubation Time：2 h
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TP0427736 HCl
Dangerous GoodsCAS number：864374-00-5 molecular formula：C14H11ClN4S2
overview
compound introduction
Specs
| Chinese alias | - | ||
| English alias | 6-[5-(4-methyl-2-thiazolyl)-1H-imidazol-4-yl]-Benzothiazole hydrochloride | ||
| CAS number | 864374-00-5 | molecular formula | C14H11ClN4S2 |
| molecular weight | 334.85 g/mol | Exact mass | 10mM in DMSO |
| PSA | 111.000 Ų | logp | 3.084 |
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Safety information
pictogram：
GHS09 , GHS07
Hazard Statement：
H302: 吞食有害 H410: 对水生生物有剧毒并具有长期持续影响
Statement of Preventive Measures：
P273: 避免释放到环境中。 P501: 将内容物/容器处理到。。。 P264: 处理后要彻底洗手。 P270: 使用本产品时，请勿进食、饮水或吸烟。 P391: 收集溢出物 P330: 漱口 P301+P312: 如误吞咽：如感觉不适，呼叫急救中心/医生。
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