PF-573228

Dangerous Goods

CAS number：869288-64-2 molecular formula：C22H20F3N5O3S

overview

Specs

numbering system

physicochemical properties

Safety information

Production methods and uses

MSDS

overview

compound introduction

PF-573228是一种ATP竞争性的FAK抑制剂，无细胞试验中IC50为4 nM，作用于FAK比作用于Pyk2，CDK1/7 和 GSK-3β选择性高~50到250倍。A potent and selective FAK (focal adhesion kinase) inhibitor. PF-573228 is an ATP-competitive inhibitor of FAK with IC50 of 4 nM in a cell-free assay, ~50- to 250-fold selective for FAK than Pyk2, CDK1/7 and GSK-3β. A potent and selective FAK (focal adhesion kinase) inhibitor.

Specs

Chinese alias	-
English alias	P4N \| PF-573228, >=95% (HPLC) \| 4-(4-nitrophenyl)-1-acetylpiperazine \| MLS006011194 \| PF-228 \| FT-0719732 \| NCGC00263133-11 \| 6-[[4-[(3-methylsulfonylphenyl)methylamino]-5-(trifluoromethyl)pyrimidin-2-yl]amino]-3,4-dihydro-1H-quinolin-2-one \| 6-[4-(3-Meth
CAS number	869288-64-2	molecular formula	C22H20F3N5O3S
molecular weight	491.49 g/mol	Exact mass	≥98%
PSA	121.000 Å²	logp	3.200

numbering system

No numbering system information yet

physicochemical properties

No physical and chemical property information yet

Safety information

pictogram：

GHS06 , GHS07

Signal word：

Danger

Hazard Statement：

H319: 引起严重眼睛刺激 H301: 吞咽会中毒

Statement of Preventive Measures：

P305+P351+P338: 如进入眼睛：用水小心冲洗几分钟。如戴隐形眼镜并可方便地取出，取出隐形眼镜。继续冲洗。 P280: 戴防护手套/穿防护服/戴防护眼罩/戴防护面具。 P321: 特殊处理（请参阅此标签上的...）。 P405: 密闭存放 P501: 将内容物/容器处理到。。。 P264: 处理后要彻底洗手。 P270: 使用本产品时，请勿进食、饮水或吸烟。 P330: 漱口 P264+P265: 处理后彻底洗手[和…]。不要触摸眼睛。 P301+P316: 如果吞咽：立即寻求紧急医疗救助。 P

WGK Germany：