CAS number：148741-30-4 molecular formula：C18H24N2OS
AG879是酪氨酸激酶的抑制剂，能够抑制TrKA的磷酸化，但不能抑制TrKB 和TrKC，也是高选择性的ErbB2激酶抑制剂。A protein tyrosine kinase inhibitor with potent effects on TrkA TyrphostinAG879 is a tyrosine kinase inhibitor that inhibits TrKA phosphorylation, but not TrKB and TrKC.[1] also a ErbB2 kinase inhibitor, has at least 500-fold higher selectivity to ErbB2 (IC50 = 1 μmol/L) than EGFR (IC50 >500 μmol/L). A protein tyrosine kinase inhibitor with potent effects on TrkA
| Chinese alias | - | ||
| English alias | 2-dicyclohexylphosphino-2',6' dimethoxybiphenyl | Tyrphostin AG 879 | 2-Propenethioamide, 3-(3,5-bis(1,1-dimethylethyl)-4-hydroxyphenyl)-2-cyano-, (E)- | alpha-Cyano-(3,5-di-t-butyl-4-hydroxy)thiocinnamide | BCP08354 | SR-01000076151-1 | BiomolKI_000028 | | ||
| CAS number | 148741-30-4 | molecular formula | C18H24N2OS |
| molecular weight | 316.46 g/mol | Exact mass | - |
| PSA | 102.000 Ų | logp | 4.700 |
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