compound introduction
PNU-74654是Wnt/β-catenin通路的的抑制剂，在NCI-H295 细胞中的IC50值为129.8 μM。 PNU-75654通过抑制β-catenin和Tcf4的相互作用（Kd=450 nM）,破坏Wnt 信号通路。 application： PNU-74654 has been used: as a β-catenin signaling inhibitor to study its effects on the funnel cartilage differentiation in Sepia sp. embryos as a Wnt signaling inhibitor to study its effects on glycogen synthase kinase 3β (GSK-3β) inhibition in prostate cancer cell lines as a Wnt signaling inhibitor to study its effects on leptin-induced cell proliferation in breast cancer cells
