Caspase-1抑制剂II（Ac-YVAD-CMK）是caspase-1（K | i | = 760 pM），caspase-4和caspase-5的细胞可渗透且不可逆的抑制剂。它还抑制Fas介导的凋亡和酸性鞘磷脂酶激活。半胱天冬酶抑制剂在研究生物学过程中起重要作用。胱天蛋白酶家族的蛋白质作为凋亡机制的关键成分，并破坏特定的靶蛋白，而靶蛋白对于细胞的寿命至关重要。Caspase-1，最初指定为ICE（用于IL-1转换酶），是具有大前结构域的caspase的成员。活性caspase-1（p20 / p10 敏感性： 对湿度和光线敏感。 Caspase-1 Inhibitor II (Ac-YVAD-CMK) is a cell-permeable and irreversible inhibitor of caspase-1 (K|i|= 760 pM), caspase-4, and caspase-5. It also inhibits Fas-mediated apoptosis and acidic sphingomyelinase activation. Caspase inhibitors play an important role in investigating biological processes. The caspase family of proteins function as key components of the apoptotic machinery and act to destroy specific target proteins which are critical to cellular longevity. Caspase-1, originally designated ICE (for IL-1 converting enzyme), is a member of the group of caspases with large prodomains. Active caspase-1, a (p20/p10)|2|tetramer, is necessary and sufficient for cleavage of precursor IL-1 as well as for induction of apoptosis in some cell lines. Following use of the inhibitor, standard apoptosis assays can be used to examine treated cells for evidence of apoptosis.|Additional caspase-1 inhibitors available:|caspase-1 inhibitor |caspase-1 inhibitor VI |Caspase-1 Inhibitor IV |Caspase-1 Inhibitor I
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Caspase-1 Inhibitor II
Dangerous GoodsCAS number：unknown molecular formula：
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| Chinese alias | N-乙酰基-酪氨酰-缬氨酰-丙氨酰-天冬氨酰 氯甲基酮肽 | Ac-Tyr-Val-Ala-Asp-氯甲基酮肽 | N-乙酰基-L-酪氨酰-L-缬氨酰-N-[(1S)-1-(羧甲基)-3-氯-2-氧基丙基]-L-丙氨酰胺 | Caspase-1 抑制剂 II | ||
| English alias | Ac-YVAD-CMK | IL-1β Converting Enzyme (ICE) Inhibitor II | ||
| CAS number | unknown | molecular formula | |
| molecular weight | - | Exact mass | ≥95% |
| PSA | - | logp | - |
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WGK Germany：
3
RTECS：
AY3079566
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