Information Inauhzin is a cell-permeableSIRT1inhibitor with an IC50 of 0.7-2 μM and reactivatesp53by inhibiting SIRT1 deacetylation activity. Targets SIRT1 ; p53 In vitro Inauhzin (INZ) is a potent p53 activator and mediates p53-dependent cytotoxicity. INZ inhibits cell proliferation by triggering both apoptosis and senescence in p53-containning cells, though it predominantly induces p53-dependent apoptosis. INZ is able to prevent p53 from MDM2-mediated ubiquitylation and proteasomal degradation and protects p53 without either directly inhibiting MDM2 activity towards p53 or interfering with MDMX/MDM2–p53 interaction. INZ induces acetylation of p53, but not tubulin, in cells. Inauhzin is a (sub)micromolar SIRT1i selective over SIRT2/3. In vivo Inauhzin (INZ) has good tumour tissue penetration and is able to inhibit tumour growth by inducing p53. Cell Research(from reference) Cell lines：human lung cancer H460, A549, H1299, colon cancer HCT116, HT29, osteosarcoma U2OS and SJSA, breast cancer MCF7, ovarian cancer A2780, IGROV1 and SKOV3 and glioma U87 and U373 cells, as well as human embryonic fibroblast WI-38 and normal human Concentrations：0-10 μM Incubation Time：18 h
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Inauhzin
Dangerous GoodsCAS number：309271-94-1 molecular formula：C25H19N5OS2
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compound introduction
Specs
| Chinese alias | 伊诺赫津 | ||
| English alias | AS-16441 | HY-N7436 | inauhzin | s6744 | 1-Phenothiazin-10-yl-2-(9H-1,3,4,9-tetraaza-fluoren-2-ylsufanyl)-butan-1-one (Inauhzin) | AC-35922 | METHIOCARB SULPHONE | UNII-KX47O2O15C | VHUOXERIKQWIJE-UHFFFAOYSA-N | INZ | Oprea1_520286 | 2-((5H-[1,2,4]triazin | ||
| CAS number | 309271-94-1 | molecular formula | C25H19N5OS2 |
| molecular weight | 469.58 g/mol | Exact mass | 10mM in DMSO |
| PSA | 125.000 Ų | logp | 5.600 |
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physicochemical properties
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Safety information
pictogram：
GHS06
Signal word：
Danger
Hazard Statement：
H301: 吞咽会中毒
Statement of Preventive Measures：
P321: 特殊处理（请参阅此标签上的...）。 P405: 密闭存放 P501: 将内容物/容器处理到。。。 P264: 处理后要彻底洗手。 P270: 使用本产品时，请勿进食、饮水或吸烟。 P330: 漱口 P301+P316: 如果吞咽：立即寻求紧急医疗救助。
WGK Germany：
3
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