FB23-2 是一种有效、选择性的 mRNA N⁶- 甲基腺嘌呤脱甲基酶 FTO 抑制剂 应用： FB23-2 具有抗增殖作用。 FB23-2 能用于急性髓系白血病 (AML) 的研究。 Information FB23-2 FB23-2 is a potent and selective FTO inhibitor that directly binds to FTO and selectively inhibits FTO's N 6 -methyladenosine (m 6 A) demethylase activity with IC50 of 2.6 μM. Targets FTO (Cell-free assay) 2.6 μM In vitro FB23-2 directly binds to FTO and selectively inhibits FTO’s m 6 A demethylase activity. Mimicking FTO depletion, FB23-2 dramatically suppresses proliferation and promotes the differentiatiopoptosis of human acute myeloid leukemia (AML) cell line cells and primary blast AML cells in vitro. In vivo FB23-2 significantly inhibits the progression of human AML cell lines and primary cells in xeno-transplanted mice. Cell Research(from reference) Cell lines：Leukemia cells NB4, U937, MV4-11, ML-2; MONOMAC6 (ACC-124) cells; 293T cells; The mouse bone marrow cells FLT3ITD/NPM1, MA9 Concentrations：10 μM, 5 μM Incubation Time：24 h, 72 h
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FB23-2
Dangerous GoodsCAS number：2243736-45-8 molecular formula：C18H15Cl2N3O3
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Specs
| Chinese alias | - | ||
| English alias | Benzamide,2-[[2,6-dichloro-4-(3,5-dimethyl-4-isoxazolyl)phenyl]amino]-N-hydroxy- | ||
| CAS number | 2243736-45-8 | molecular formula | C18H15Cl2N3O3 |
| molecular weight | 392.24 g/mol | Exact mass | 10mM in DMSO |
| PSA | 87.400 Ų | logp | 4.124 |
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Safety information
pictogram：
GHS07
Signal word：
Warning
Hazard Statement：
H315: 引起皮肤刺激 H319: 引起严重眼睛刺激 H335: 可能引起呼吸道刺激
Statement of Preventive Measures：
P261: 避免吸入灰尘/烟雾/气体/雾/蒸汽/喷雾 P305+P351+P338: 如进入眼睛：用水小心冲洗几分钟。如戴隐形眼镜并可方便地取出，取出隐形眼镜。继续冲洗。
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