Information EN4 EN4, a covalent ligand that targets cysteine 171 (C171) of MYC , is selective for c-MYC over N-MYC and L-MYC. EN4 inhibits MYC transcriptional activity, downregulates MYC targets, and impairs tumorigenesis. Targets MYC In vitro EN4 directly targets MYC in cells, reduces MYC and MAX thermal stability, inhibits MYC transcriptional activity, downregulates multiple MYC transcriptional targets, and impairs tumorigenesis. EN4 treatment significantly impairs 231MFP breast cancer cell proliferation in a dose- and time-dependent manner. EN4 impairs the cell survival of MYC transformed mammary epithelial MCF10A cells, but not parental MCF10A cells that are not dependent on MYC. In vivo EN4 treatment initiated after establishment of a 231MFP breast tumor xenograft in immune-deficient mice also significantly attenuates tumor growth in vivo. Cell Research(from reference) Cell lines：231MFP, MDA-MB-231, HEK293T and MCF10A cells Concentrations：50 μM Incubation Time：24 h
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EN4
Dangerous GoodsCAS number：1197824-15-9 molecular formula：C25H24N2O4
overview
compound introduction
Specs
| Chinese alias | - | ||
| English alias | MS-27247 | N-[2-(4-ethoxyphenoxy)phenyl]-4-[(prop-2-enoylamino)methyl]benzamide | benzamide,n-(2-(4-ethoxyphenoxy)phenyl)-4-(((1-oxo-2-propen-1-yl)amino)methyl)- | N-[2-(4-ethoxyphenoxy)phenyl]-4-[(prop-2-enamido)methyl]benzamide | SCHEMBL21392882 | EN300 | ||
| CAS number | 1197824-15-9 | molecular formula | C25H24N2O4 |
| molecular weight | 416.47 g/mol | Exact mass | 10mM in DMSO |
| PSA | 76.700 Ų | logp | 4.332 |
numbering system
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physicochemical properties
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Safety information
pictogram：
GHS07
Signal word：
Warning
Hazard Statement：
H315: 引起皮肤刺激 H319: 引起严重眼睛刺激 H335: 可能引起呼吸道刺激 H302: 吞食有害
Statement of Preventive Measures：
P261: 避免吸入灰尘/烟雾/气体/雾/蒸汽/喷雾 P305+P351+P338: 如进入眼睛：用水小心冲洗几分钟。如戴隐形眼镜并可方便地取出，取出隐形眼镜。继续冲洗。 P280: 戴防护手套/穿防护服/戴防护眼罩/戴防护面具。 P302+P352: 如皮肤沾染：用水充分清洗。 P321: 特殊处理（请参阅此标签上的...）。 P405: 密闭存放 P501: 将内容物/容器处理到。。。 P264: 处理后要彻底洗手。 P271: 仅在室外或通风良好的地方使用。 P270: 使用本产品时，请勿进食、饮水
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MSDS
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