Information HS-1371 HS-1371 is a potent RIP3 kinase inhibitor with an IC50 of 20.8 nM. It binds to the ATP binding pocket of RIP3 and inhibits ATP binding to prevent RIP3 enzymatic activity in vitro. Targets RIP3 kinase 20.8 nM In vitro HS-1371 shows an inhibitory effect on S227 auto-phosphorylation of RIP3 at the basal level. It displays a complete inhibitory effect on TNF-induced necroptosis signaling, showing no phosphorylation of RIP3 and MLKL in HT-29 cells. Inhibition of RIP3 kinase activity by HS-1371 blocks necrosome complex formation, showing disruption of MLKL recruitment. HS-1371 rescues cells from TNF-induced necroptosis. It rescues cells from RIP3-dependent necroptotic cell death but not apoptotic cell death. Cell Research(from reference) Cell lines：HT-29 cells Concentrations：5 μM Incubation Time：2 h
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HS-1371
Dangerous GoodsCAS number：2158197-70-5 molecular formula：C24H24N4O
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Specs
| Chinese alias | - | ||
| English alias | Quinoline,4-(4-methylphenoxy)-7-[1-(4-piperidinyl)-1H-pyrazol-4-yl]- | ||
| CAS number | 2158197-70-5 | molecular formula | C24H24N4O |
| molecular weight | 384.47 g/mol | Exact mass | ≥98% |
| PSA | 52.000 Ų | logp | 3.805 |
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physicochemical properties
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Safety information
pictogram：
GHS07
Signal word：
Warning
Hazard Statement：
H315: 引起皮肤刺激 H319: 引起严重眼睛刺激 H335: 可能引起呼吸道刺激
Statement of Preventive Measures：
P261: 避免吸入灰尘/烟雾/气体/雾/蒸汽/喷雾 P305+P351+P338: 如进入眼睛：用水小心冲洗几分钟。如戴隐形眼镜并可方便地取出，取出隐形眼镜。继续冲洗。
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