iCRT3

Dangerous Goods

CAS number：901751-47-1 molecular formula：C23H26N2O2S

overview

Specs

numbering system

physicochemical properties

Safety information

Production methods and uses

MSDS

overview

compound introduction

Information iCRT3 iCRT3 is an antagonist of Wnt/β-catenin signaling with an IC50 of 8.2 nM in the Wnt responsive STF16-luc reporter assays. Targets Wnt/β-catenin (in STF16 assay) 8.2 nM In vitro iCRT3 is a small molecule inhibitor of the Wnt pathway which binds to β-catenin interfering with its interaction with TCF. iCRT3 significantly reduces the LPS-induced Wnt/β-catenin activity and also inhibits TNF-α production and IκB degradation in a dose-dependent manner. iCRT3 does not influence the transcriptional activity of FOP-Flash luciferase reporter, which harbors mutations in the DNA binding sites for TCF (β-cat response element), showing specificity of the response. It inhibits cytokine production in LPS-stimulated macrophages. In vivo Intraperitoneal administration of iCRT3 to C57BL/6 mice, subjected to cecal ligation and puncture-induced sepsis, decreases the plasma levels of proinflammatory cytokines and organ injury markers in a dose-dependent manner. The histological integrity of the lungs is improved with iCRT3 treatment, along with reduced lung collagen deposition and apoptosis. In addition, iCRT3 treatment also decreases the expression of the cytokines, neutrophil chemoattractants, as well as the MPO activity in the lungs of septic mice. Cell Research(from reference) Cell lines：HCT116 cells Concentrations：25, 50, 75 μM Incubation Time：1 days

Specs

Chinese alias	-
English alias	AC-35700 \| BS-17818 \| SCHEMBL12007212 \| HMS1500N09 \| BRD-K35271190-001-01-9 \| 2-({[2-(4-ETHYLPHENYL)-5-METHYL-1,3-OXAZOL-4-YL]METHYL}SULFANYL)-N-(2-PHENYLETHYL)ACETAMIDE \| 2-[[2-(4-ethylphenyl)-5-methyl-1,3-oxazol-4-yl]methylsulfanyl]-N-(2-phenylethyl)ace
CAS number	901751-47-1	molecular formula	C23H26N2O2S
molecular weight	394.53 g/mol	Exact mass	≥98%
PSA	80.400 Å²	logp	5.000

numbering system

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physicochemical properties

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Safety information

pictogram：

GHS05 , GHS07

Signal word：

Danger

Hazard Statement：

H315: 引起皮肤刺激 H335: 可能引起呼吸道刺激 H302: 吞食有害 H318: 造成严重的眼睛损伤

Statement of Preventive Measures：

P261: 避免吸入灰尘/烟雾/气体/雾/蒸汽/喷雾 P280: 戴防护手套/穿防护服/戴防护眼罩/戴防护面具。 P302+P352: 如皮肤沾染：用水充分清洗。 P321: 特殊处理（请参阅此标签上的...）。 P405: 密闭存放 P501: 将内容物/容器处理到。。。 P264: 处理后要彻底洗手。 P271: 仅在室外或通风良好的地方使用。 P270: 使用本产品时，请勿进食、饮水或吸烟。 P304+P340: 如误吸入：将人转移到空气新鲜处，保持呼吸舒适体位。 P403+P233: 存放在通风良

WGK Germany：