CAS number：217645-70-0 molecular formula：C21H24ClFN4O3
产品介绍 BX471 (ZK-811752) 是选择性，非多肽的 CCR1 拮抗剂，Ki 值为 1 nM，对其选择性是对 CCR2，CCR5 和 CXCR4 的 250 倍。 Product Application BX471 has been used in chemotaxis assay to study the responses of HEK293 cells expressing human C-C motif chemokine receptor 1 (CCR1) to CC motif ligand 3 (CCL3)-induced cell migration. It has also been used as a CCR1 inhibitor to assess the effects of CCR1 on the migration and epithelial-mesenchymal transition (EMT).
| Chinese alias | (R)-1-[5-氯-2-[2-[4-(4-氟苄基)-2-甲基哌嗪-1-基]-2-氧代乙氧基]苯基]脲 | (2R)-1-[[[2-[(氨基羰基)氨基] -4-氯苯氧基]乙酰基] -4-[(4-氟苯基)甲基] -2-甲基哌嗪 | ||
| English alias | BX471 | BX-471 | BX-471 free base | BX 471 | (R)-1-(5-chloro-2-(2-(4-(4-fluorobenzyl)-2-methylpiperazin-1-yl)-2-oxoethoxy)phenyl)urea | ZK-811752 | [5-chloro-2-[2-[(2R)-4-[(4-fluorophenyl)methyl]-2-methylpiperazin-1-yl]-2-oxoethoxy]phenyl]urea | BX-741 | ||
| CAS number | 217645-70-0 | molecular formula | C21H24ClFN4O3 |
| molecular weight | 434.89 g/mol | Exact mass | - |
| PSA | 87.900 Ų | logp | 2.500 |
No numbering system information yet
No physical and chemical property information yet
No production method and use information yet
No upstream information yet
No downstream information yet
