S0859 是一种选择性的，高亲和力的 Na+/HCO3- 共转运体 (NBC) 抑制剂，可逆性地抑制 NBC 介导的细胞内 pH (pHi) 恢复 (Ki=1.7 μM，完全抑制在 30 μM)。 S0859, an N-cyanosulphonamide compound, reversibly inhibited NBC-mediated pH(i) recovery (K (i)=1.7 microM, full inhibition at approximately 30 microM). Na(+)-coupled HCO(3)(-) transporters (NBCs) mediate the transport of bicarbonate ions across cell membranes and are thus ubiquitous regulators of intracellular pH. NBC dysregulation is associated with a range of diseases; for instance, NBCn1 is strongly up-regulated in a model of ErbB2-dependent breast cancer, a malignant and widespread cancer with no targeted treatment options, and single-nucleotide polymorphisms in NBCn1 genetically link to breast cancer development and hypertension. Treatment with NBC inhibitor S0859 significantly increased caspase-3 activity and elevated the number of apoptotic EC. S0859 is potentially important for probing the transporter's functional role in heart and other tissues.
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S0859
Dangerous GoodsCAS number：1019331-10-2 molecular formula：C29H24ClN3O3S
overview
compound introduction
Specs
| Chinese alias | - | ||
| English alias | MFCD23136018 | DTXSID90742624 | 2-Chloro-N-((2'-(N-cyanosulfamoyl)-[1,1'-biphenyl]-4-yl)methyl)-N-(4-methylbenzyl)benzamide | AKOS025149449 | 1019331-10-2 | AS-16469 | 2-chloro-N-((2'-(N-cyanosulfamoyl)biphenyl-4-yl)methyl)-N-(4-methylbenzyl)benzamide | 2 | ||
| CAS number | 1019331-10-2 | molecular formula | C29H24ClN3O3S |
| molecular weight | 530.04 g/mol | Exact mass | ≥98% |
| PSA | 98.700 Ų | logp | 6.000 |
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Safety information
Hazard Statement：
H413: 可能对水生生物造成长期的有害影响
WGK Germany：
3
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