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(+/-)-JQ1

Dangerous Goods

CAS number：1268524-69-1    molecular formula：C23H25ClN4O2S

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overview

compound introduction

通过分析其对脂肪形成的基因调控的影响，特别是对过氧化物酶体增殖物激活受体 (PPAR-g)、CCAAT/增强子结合蛋白(C/EBPa)以及STAT5A和B的影响，(±)-JQ1已被用来研究其对脂肪形成的影响。JQ1已作为BRD4化学抑制剂用于药物结合试验，以研究CRBN在小鼠和人类中的底物募集功能。 生化/生理作用： (+/-)-JQ1 是 Brd4 抑制剂。 (±)-JQ1 是 Brd4 抑制剂。已知 JQ1 抑制细胞增殖，因此，可用作编号癌症的治疗药物，包括多发性骨髓瘤和急性髓性白血病。 (±)-JQ1 has been used to study its effect on adipogenesis, by analyzing the its impact on the regulation of genes involved in this process especially peroxisome proliferator-activated receptor (PPAR-g), the CCAAT/enhancer-binding protein (C/EBPa) and, STAT5A and B. JQ1 has been used in drug binding assays as a chemical inhibitor of BRD4 to study the CRBN’s substrate recruiting function in mouse and human. Biochemical/physiological effects: (+/-)-JQ1 is a Brd4 inhibitor. (±)-JQ1 is a Brd4 inhibitor. JQ1 is known to suppress cell proliferation and therefore, can be used as a therapeutic drug for a number of cancers including multiple myeloma and acute myeloid leukemia.

Specs

Chinese alias[(R,S)-4-（4-氯苯基）-2,3,9-三甲基-6H-1-硫杂-5,7,8,9a-四氮杂-环戊环[e]氮杂-6-基]-乙酸叔丁酯 | N-(2′,5′-二甲氧基 [1,1′-联苯 ]-4-基）-3-氟-4-吡啶甲酰胺
English aliasHMS3747M15 | tert-Butyl 2-[4-(4-Chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl]acetate | 6H-Thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine-6-acetic acid, 4-(4-chlorophenyl)-2,3,9-trimethyl-, 1,1-dimethylethyl est
CAS number1268524-69-1molecular formulaC23H25ClN4O2S
molecular weight456.99 g/molExact mass≥98%(HPLC)
PSA97.600 Ųlogp4.900

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WGK Germany：
3

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