Filibuvir is an orally active, selective non-nucleoside inhibitor of the HCV nonstructural 5B protein (NS5B) RNA-dependent RNA polymerase (RdRp). Filibuvir binds noncovalently in the thumb II allosteric pocket of NS5B. Filibuvir inhibits genotype 1a and 1b replicons with EC 50 s of 59 nM for both isoforms, respectively. Filibuvir preferentially inhibits elongative RNA synthesis and potently decreases viral RNA accumulation . In Vitro Filibuvir (0.01-10000 nM; 48 h) inhibits the WT 1b replicon in a dose-dependent manner, with an EC 50 of ∼70 nM in Huh7.5 cells harboring the HCV replicon. Filibuvir binds to the HCV polymerase with a dissociation constant of 29 nM. Filibuvir preferentially inhibits elongative RNA synthesis rather than de novo-initiated RNA synthesis. Filibuvir has no obvious effect on de novo-initiated RNA synthesis (IC 50 =∼5 μM) but decreases primer extension from PE46, with an IC 50 of 73 nM. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid
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Filibuvir
Dangerous GoodsCAS number：877130-28-4 molecular formula：C29H37N5O3
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| Chinese alias | 菲利布韦 | ||
| English alias | HY-10118 | 2H-Pyran-2-one, 6-cyclopentyl-6-(2-(2,6-diethyl-4-pyridinyl)ethyl)-3-((5,7-dimethyl(1,2,4)triazolo(1,5-a)pyrimidin-2-yl)methyl)-5,6-dihydro-4-hydroxy-, (6R)- | Q24975766 | DTXSID601007768 | (2R)-2-cyclopentyl-2-[2-(2,6-diethylpyridin-4-yl)ethyl | ||
| CAS number | 877130-28-4 | molecular formula | C29H37N5O3 |
| molecular weight | 503.64 g/mol | Exact mass | - |
| PSA | 103.000 Ų | logp | 5.600 |
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