compound introduction
有力地（低nM）增强了α4β3δ受体介导的GABA诱发的电流。它对由α4β32受体介导的GABA反应的影响很小。在相似的浓度下，DS1直接激活该受体，并且是已知最有效的α4β3δ受体激动剂。该化合物有机会成为δ-GABA| A |受体的激动剂金标准品。 Potently (low nM) enhances GABA-evoked currents mediated by α4β3δ receptors. It has little effect on GABA responses mediated by α4β3 2 receptors. At similar concentrations, DS1 directly activates this receptor and is the most potent known agonist of α4β3δ receptors. This compound has an opportunity to be become an agonist golden stardard for δ-GABA|A|receptors.
