CAS number：1187594-09-7 molecular formula：C16H17N7O2S
Baricitinib (LY3009104, INCB028050)是一种选择性的JAK1和JAK2抑制剂，IC50分别为5.9 nM和5.7 nM，比作用于JAK3和Tyk2选择性高70和10倍左右，对c-Met和Chk2没有抑制作用。A selective inhibitor of JAK1 and JAK2. Baricitinib (LY3009104, INCB028050) is a selective JAK1 and JAK2 inhibitor with IC50 of 5.9 nM and 5.7 nM, ~70 and ~10-fold selective versus JAK3 and Tyk2, no inhibition to c-Met and Chk2. A selective inhibitor of JAK1 and JAK2.
| Chinese alias | 1-(乙基磺酰基)-3-[4-(7H-吡咯并[2,3-d]嘧啶-4-基)-1H-吡唑-1-基]-3-氮杂环丁烷乙腈 | 2-(3-(4-(3H-吡咯并[2,3-d]嘧啶-4-基)-1H-吡唑-1-基)-1-(乙基磺酰)吖丁啶-3-基)乙腈 | ||
| English alias | DB11817 | GTPL7792 | HMS3672M15 | LY3009104 | LY-3009104 | Z2724205326 | 2-[1-ETHYLSULFONYL-3-[4-(7H-PYRROLO[2,3-D]PYRIMIDIN-4-YL)PYRAZOL-1-YL]AZETIDIN-3-YL]ACETONITRILE | DTXCID5074719 | L04AA37 | (1-(Ethylsulfonyl)-3-(4-(7H-pyrrolo(2,3-d)pyrimidin-4-yl) | ||
| CAS number | 1187594-09-7 | molecular formula | C16H17N7O2S |
| molecular weight | 371.42 g/mol | Exact mass | - |
| PSA | 129.000 Ų | logp | -0.5 |
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