Radotinib (IY-5511) 是一种选择性 BCR-ABL1 酪氨酸激酶抑制剂，IC50 为 34 nM，用于治疗慢性髓性白血病。 Information Radotinib Radotinib (IY-5511) is a selective BCR-ABL1 tyrosine kinase inhibitor with IC50 of 34 nM, used to treat Chronic Myeloid Leukemia. Targets BCR-ABL1 34 nM In vitro Radotinib binds BCR-ABL1 and reduces phosphorylation of CrkL, a BCR-ABL1 target protein. Radotinib also effectively inhibits the proliferation of common mutant clones of BCR-ABL1, with the exception of T315I. In AML cells, radotinib significantly decreases the cell viability, promotes differentiation, and induces CD11b expression and apoptosis. In NB4, THP-1, and Kasumi-1 cells, radotinib also induces CD11b expression, and decreases the viability. Cell Research(from reference) Cell lines：BMCs of AML and CML patients, NB4, HL60, KASUMI-1, and THP-1 cells Concentrations：~100 μM Incubation Time：72 h
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Radotinib
Dangerous GoodsCAS number：926037-48-1 molecular formula：C27H21F3N8O
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| Chinese alias | 雷多替尼 | ||
| English alias | NCGC00481590-01 | Radotinib | 2?,3?,17?-Trihydroxy-7?-6-oxo-5?-androstan | Radotinib [INN] | Radotinib(IY-5511) | MFCD11114059 | NSC800989 | NSC-800989 | UNII-I284LJY110 | 4-methyl-N-(3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl)-3-((4-(pyrazin | ||
| CAS number | 926037-48-1 | molecular formula | C27H21F3N8O |
| molecular weight | 530.5 g/mol | Exact mass | - |
| PSA | 111.000 Ų | logp | 4.362 |
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Safety information
pictogram：
GHS07
Signal word：
Warning
Hazard Statement：
H315: 引起皮肤刺激 H319: 引起严重眼睛刺激 H335: 可能引起呼吸道刺激 H302: 吞食有害
Statement of Preventive Measures：
P261: 避免吸入灰尘/烟雾/气体/雾/蒸汽/喷雾 P305+P351+P338: 如进入眼睛：用水小心冲洗几分钟。如戴隐形眼镜并可方便地取出，取出隐形眼镜。继续冲洗。
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