PD 404182 is a potent and competitive inhibitor of human dimethylarginine dimethylaminohydrolase 1 (DDAH1) , with an IC 50 of 9 μM. PD 404182 exhibits antiangiogenic and antiviral activity in vitro In Vitro PD 404182 (20 μM) increases asymmetric dimethylarginine (ADMA) approximately 70% in ECs. PD 404182 (50-100 μM; 18 hours) attenuates endothelial tube formation in virto and does not perturb cell membrane integrity or induces cytotoxicity. PD 404182 inhibits HIV-1 in seminal plasma, with an IC 50 of 1 μM. PD 404182 (300 μM;30 minutes) exhibits low toxicity toward several human cell lines , freshly activated PBMCs, primary CD 4+ T lymphocytes, macrophages, and dendritic cells, and lactobacilli found in the normal vaginal flora. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Cell Viability AssayCell Line: Human dermal microvascular endothelial cells (ECs) Concentration: 10-300 μM Incubation Time: 24 hours Result: Did not induce cytotoxicity. Form:Solid IC50& Target:IC50: 9 μM (DDAH1)
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PD 404182
Dangerous GoodsCAS number：72596-74-8 molecular formula：C11H11N3S
overview
compound introduction
Specs
| Chinese alias | 零件编号 404182 | ||
| English alias | DTXSID00424969 | NCGC00015809-03 | DTXSID8061137 | Lopac0_000947 | NCGC00015809-01 | SCHEMBL4097420 | PD 404,182 | PD 404182 | 9-thia-3,7-diazatricyclo[8.4.0.0?,?]tetradeca-1(10),2,11,13-tetraen-8-imine | NCGC00015809-02 | 2H,6H-Pyrimido(1,2-C)(1,3)benzot | ||
| CAS number | 72596-74-8 | molecular formula | C11H11N3S |
| molecular weight | 217.29 g/mol | Exact mass | ≥98% |
| PSA | 64.800 Ų | logp | 1.900 |
numbering system
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physicochemical properties
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Safety information
pictogram：
GHS07
Signal word：
Warning
Hazard Statement：
H315: 引起皮肤刺激 H319: 引起严重眼睛刺激 H335: 可能引起呼吸道刺激
Statement of Preventive Measures：
P261: 避免吸入灰尘/烟雾/气体/雾/蒸汽/喷雾 P305+P351+P338: 如进入眼睛：用水小心冲洗几分钟。如戴隐形眼镜并可方便地取出，取出隐形眼镜。继续冲洗。 P280: 戴防护手套/穿防护服/戴防护眼罩/戴防护面具。 P302+P352: 如皮肤沾染：用水充分清洗。 P321: 特殊处理（请参阅此标签上的...）。 P405: 密闭存放 P501: 将内容物/容器处理到。。。 P264: 处理后要彻底洗手。 P271: 仅在室外或通风良好的地方使用。 P304+P340: 如误吸入：将人转移
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Related
upstream information
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downstream information
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MSDS
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