c-Myc Max相互作用抑制剂。c-Myc癌蛋白及其伴侣Max是本质上无序的（ID）单体，它们在异二聚作用后会发生折叠和结合。与10058-F4类似，10074-G5通过与c-Myc结合来特异性抑制这种相互作用，从而阻止C-Myc特异性DNA结合和靶基因调控。10074-G5（2.8 microM）比10058-F4（5.2 microM）更有力，这是由于10074-G5与10054-F4结合的C-Myc区域不同。因此，对于探测不同的相互作用，该化合物可能变得合乎需要。 A c-Myc Max interaction inhibitor. The c-Myc oncoprotein and its partner Max are intrinsically disordered (ID) monomers that undergo coupled folding and binding upon heterodimerization. 10074-G5, similarly to 10058-F4, specifically inhibits this interaction by binding to c-Myc, thus preventing C-Myc specific DNA binding and target genes regulation. 10074-G5 (2.8 microM) is slightly more potent that 10058-F4 (5.2 microM) most likely due to the fact that 10074-G5 binds to a different region of C-Myc than 10054-F4. Thus, the compound may become desirable for probing different interactions.
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10074-G5
Dangerous GoodsCAS number：413611-93-5 molecular formula：C18H12N4O3
overview
compound introduction
Specs
| Chinese alias | - | ||
| English alias | Biphenyl-2-yl-(7-nitrobenzo[1,2,5]oxadiazol-4-yl)amine | s8426 | SCHEMBL2689577 | SMR004704145 | 10074-G5, >=98% (HPLC) | Oprea1_158245 | NSC764609 | NSC-764609 | N-2-Biphenylyl-7-nitro-2,1,3-benzoxadiazol-4-amine | MFCD00576774 | AKOS032946699 | DTXSID60 | ||
| CAS number | 413611-93-5 | molecular formula | C18H12N4O3 |
| molecular weight | 332.31 g/mol | Exact mass | 10mM in DMSO |
| PSA | 96.800 Ų | logp | 4.200 |
numbering system
No numbering system information yet
physicochemical properties
No physical and chemical property information yet
Safety information
pictogram：
GHS06 , GHS07
Signal word：
Danger
Hazard Statement：
H315: 引起皮肤刺激 H319: 引起严重眼睛刺激 H335: 可能引起呼吸道刺激 H301: 吞咽会中毒
Statement of Preventive Measures：
P261: 避免吸入灰尘/烟雾/气体/雾/蒸汽/喷雾 P305+P351+P338: 如进入眼睛：用水小心冲洗几分钟。如戴隐形眼镜并可方便地取出，取出隐形眼镜。继续冲洗。 P280: 戴防护手套/穿防护服/戴防护眼罩/戴防护面具。 P302+P352: 如皮肤沾染：用水充分清洗。 P321: 特殊处理（请参阅此标签上的...）。 P405: 密闭存放 P501: 将内容物/容器处理到。。。 P264: 处理后要彻底洗手。 P271: 仅在室外或通风良好的地方使用。 P270: 使用本产品时，请勿进食、饮水
Production methods and uses
No production method and use information yet
Related
upstream information
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downstream information
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MSDS
Found 0 shareMSDS
