compound introduction
Vacuolin-1是一种溶酶体胞吐抑制剂，可防止溶酶体的Ca | 2+ |依赖性融合与质膜并防止溶酶体含量的释放。Vacuolin-1改变了溶酶体的形态，但没有改变细胞的重密封。Vacuolin-1具有细胞渗透性。Vacuolin-1不会干扰肌动蛋白或微管蛋白细胞骨架网络的组织。Vacuolin-1也不会干扰沿内吞或分泌途径的运输。 Vacuolin-1 is a lysosomal exocytosis inhibitor that prevents Ca|2+|-dependent fusion of lysosomes with the plasma membrane and the release of lysosomal content. Vacuolin-1 alters the morphology of lysosomes, but not their cell resealing. Vacuolin-1 is cell-permeable. Vacuolin-1 does not disturb the organization of the actin or tubulin cytoskeletal networks. Vacuolin-1 also does not interfere with trafficking along the endocytic or secretory pathways.
