蛇孢菌素A是植物病原性真菌产生的一类植物毒性代谢产物的主要成员。蛇孢菌素A在钙调节中起钙调蛋白作用的抑制剂的作用。微生物筛选技术公司的内部测试表明，蛇孢菌素A具有广泛的生物学特性，具有抗菌，抗真菌，抗肿瘤和杀线虫活性。蛇孢菌素A阻断钙调蛋白依赖性磷酸二酯酶的激活，IC50值为9μM。蛇孢菌素A通过与保守的赖氨酸残基共价结合来拮抗植物和动物的多种形式的钙调蛋白。 Ophiobolin A is the dominant member of a class of phytotoxic metabolites produced by plant pathogenic fungi. Ophiobolin A acts as an inhibitor of calmodulin action in calcium regulation. In-house testing at Microbial Screening Technologies has shown that Ophiobolin A possesses a broad biological profile with antibacterial, antifungal, antitumor and nematocidal activiites. Ophiobolin A blocks the activation of calmodulin-dependent phosphodiesterase with an IC50 value of 9 μM. Ophiobolin A antagonizes a variety of forms of calmodulin from plants and animals by binding covalently to conserved lysine residues.
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Ophiobolin A
Dangerous GoodsCAS number：4611-05-6 molecular formula：C25H36O4
overview
compound introduction
Specs
| Chinese alias | - | ||
| English alias | C09145 | (1'R,2S,3S,3'S,4'R,5R,7'S,8'E,11'R)-4'-hydroxy-1',3,4'-trimethyl-5-(2-methylprop-1-enyl)-6'-oxospiro[oxolane-2,12'-tricyclo[9.3.0.03,7]tetradec-8-ene]-8'-carbaldehyde | AKOS040742342 | Ophiobolin | Q27107581 | Cochliobolin | Spiro(dicyclopenta(a, | ||
| CAS number | 4611-05-6 | molecular formula | C25H36O4 |
| molecular weight | 400.55 g/mol | Exact mass | - |
| PSA | 63.600 Ų | logp | 3.500 |
numbering system
No numbering system information yet
physicochemical properties
No physical and chemical property information yet
Safety information
pictogram：
GHS06 , GHS07
Signal word：
Danger
Hazard Statement：
H301: 吞咽会中毒 H312: 皮肤接触有害 H332: 吸入有害
Statement of Preventive Measures：
P261: 避免吸入灰尘/烟雾/气体/雾/蒸汽/喷雾 P280: 戴防护手套/穿防护服/戴防护眼罩/戴防护面具。 P302+P352: 如皮肤沾染：用水充分清洗。 P321: 特殊处理（请参阅此标签上的...）。 P405: 密闭存放 P501: 将内容物/容器处理到。。。 P264: 处理后要彻底洗手。 P271: 仅在室外或通风良好的地方使用。 P270: 使用本产品时，请勿进食、饮水或吸烟。 P304+P340: 如误吸入：将人转移到空气新鲜处，保持呼吸舒适体位。 P362+P364: 脱掉沾污的衣
WGK Germany：
3
RTECS：
RL1576000
Production methods and uses
No production method and use information yet
Related
upstream information
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downstream information
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MSDS
Found 0 shareMSDS
