Vilanterol Trifenate

Dangerous Goods

CAS number：503070-58-4 molecular formula：C24H33Cl2NO5.C20H16O2

overview

Specs

numbering system

physicochemical properties

Safety information

Production methods and uses

MSDS

overview

compound introduction

Information Vilanterol trifenatate (GW642444M) is a novel inhaled long-actingbeta2 adrenoceptoragonist with inherent 24-hour activity for once daily treatment of COPD and asthma. Targets β2-adrenoceptor In vitro Vilanterol displays a subnanomolar affinity for the β2-AR that is comparable with that of salmeterol but higher than olodaterol, formoterol, and indacaterol. In cAMP functional activity studies, vilanterol demonstrates similar selectivity as salmeterol for β2- over β1-AR and β3-AR, but a significantly improved selectivity profile than formoterol and indacaterol. Vilanterol also shows a level of intrinsic efficacy that is comparable to indacaterol but significantly greater than that of salmeterol. In cellular cAMP production and tissue-based studies measuring persistence and reassertion, vilanterol has a persistence of action comparable with indacaterol and longer than formoterol. In addition, vilanterol demonstrates reassertion activity in both cell and tissue systems that is comparable with salmeterol and indacaterol but longer than formoterol. In human airways, vilanterol is shown to have a faster onset and longer duration of action than salmeterol, exhibiting a significant level of bronchodilation 22 h after treatment.

Specs

Chinese alias	-
English alias	Triphenylacetic acid-4-((1R)-2-((6-(2-((2,6-Dichlorobenzyl)oxy)ethoxy)hexyl)amino)-1-hydroxyethyl)-2-(hydroxymethyl)phenol (1:1) \| Vilanterol trifenatate (JAN/USAN) \| 40AHO2C6DG \| Triphenylacetic acid--4-{(1R)-2-[(6-{2-[(2,6-dichlorophenyl)methoxy]ethoxy}
CAS number	503070-58-4	molecular formula	C24H33Cl2NO5.C20H16O2
molecular weight	774.77 g/mol	Exact mass	10mM in DMSO
PSA	128.000 Å²	logp	5.949

numbering system

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physicochemical properties

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Safety information

pictogram：

GHS08 , GHS09 , GHS05 , GHS07

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Danger

Hazard Statement：

H315: 引起皮肤刺激 H341: 怀疑引起遗传缺陷 H373: 通过长时间或反复暴露对器官造成损害 H411: 对水生生物有毒并具有长期持续影响 H413: 可能对水生生物造成长期的有害影响 H302: 吞食有害 H318: 造成严重的眼睛损伤 H317: 可能引起皮肤过敏反应 H334: 吸入可能引起过敏或哮喘病症状或呼吸困难 H400: 对水生生物有剧毒 H410: 对水生生物有剧毒并具有长期持续影响 H370: 对器官造成损害 H361: 怀疑破坏生育力或未出生的孩子

Statement of Preventive Measures：

P261: 避免吸入灰尘/烟雾/气体/雾/蒸汽/喷雾 P273: 避免释放到环境中。 P280: 戴防护手套/穿防护服/戴防护眼罩/戴防护面具。 P302+P352: 如皮肤沾染：用水充分清洗。 P321: 特殊处理（请参阅此标签上的...）。 P405: 密闭存放 P501: 将内容物/容器处理到。。。 P264: 处理后要彻底洗手。 P260: 不要吸入灰尘/烟雾/气体/雾/蒸汽/喷雾。 P284: 如果通风不良，请佩戴呼吸防护装置。 P281: 根据需要使用个人防护设备。 P270: 使用本产品时，