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Product introduction
三氯噻嗪是一种苯并噻二嗪,在2、3和4位被氢化,并在C-7位被氨基磺酰基取代,在C-6位被氯取代基取代,在C-3位被二氯甲基取代,S-1为S,S-二氧化物。作为一种磺胺类抗生素,它用作利尿剂治疗水肿(包括与心力衰竭相关的水肿)和高血压。它具有利尿剂和降压剂的作用。它是一种苯并噻二嗪和磺胺类抗生素。
Chinese name
三氯噻嗪, 对噻嗪类药物敏感的钠氯共转运抑制剂
English name
6-chloro-3-(dichloromethyl)-1,1-dioxo-3,4-dihydro-2H-1lambda6,2,4-benzothiadiazine-7-sulfonamide
Chinese alias
三氯噻嗪
English alias
Intromene | 3-(Dichloromethyl)-6-chloro-7-sulfamoyl-3,4-dihydro-1,2,4-benzothiadiazine 1,1-dioxide | BPBio1_000825 | Spectrum_000520 | Achletin | Cretonin | TRICHLORMETHIAZIDE (MART.) | Aponorin | Ciba 7057-Su | SPECTRUM1500590 | (+-)-6-Chloro-3-(dichloro
CAS number
133-67-5
molecular formula
C8H8Cl3N3O4S2
molecular weight
380.7
Exact mass
-
PSA
135
Logp
0.6
Safety
  • Storage conditions: 三氯噻嗪片应储存在密闭容器中,温度低于40°C,最好在15-30°C之间。
  • Disposal method: SRP:在审查时,土地处理或填埋(卫生填埋)处置实践的标准正在重大修订中。在实施废物残渣(包括废物污泥)的土地处置之前,咨询环境监管机构以获取可接受的处置实践指导。
  • Regulatory information: 新西兰化学品清单状态:三氯噻嗪:没有单独批准,但可在适当的团体标准下使用
  • Human toxicity extract: 可能抑制泌乳,但与母乳喂养兼容/SRP:/。/噻嗪类利尿剂,来自表格/
  • Other safety information: 化学品评估:IMAP评估 - 2H-1,2,4-苯并噻二嗪-7-磺酰胺,6-氯-3-(二氯甲基)-3,4-二氢-, 1,1-二氧化物:环境I级评估
  • non-human toxicity value: LD50 小鼠静脉注射 750 mg/kg
  • Hazard categories and classifications: 呼吸道致敏物 1 (95.1%)
  • Non-human toxic extract: 高剂量在大鼠和狗的试验中会引发高血糖和糖尿。
  • Antidote and first aid: 噻嗪类利尿剂过量应立即进行胃排空,然后进行支持性对症治疗,并监测血清电解质浓度和肾功能。/噻嗪类利尿剂/
  • Drug Induced Liver Injury: 参考文献:DOI:10.1016/j.drudis.2019.09.022
  • Effects During Pregnancy and Lactation: 截至修订日期,未找到关于三氯噻嗪的相关已发表信息。噻嗪类和噻嗪样利尿剂、限制液体摄入和乳房束缚已被用于抑制产后泌乳。利尿剂对这些有效的泌乳抑制措施的附加贡献尚未研究。关于利尿剂对已建立的、持续的泌乳的影响没有数据。
Related
upstream information
Manufacturing method:
二氯乙醛(CID:6576);氯仿(CID:6407)
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Research chemical ≥98. 0%; 100mg

Research chemical ≥98. 0%; 100mg; supplied for laboratory research, analysis, inspection, and scientific procurement use; specifications: ≥98. 0%; 100mg.

item number:710200
Product model:100mg
level: ≥98. 0%; 100mg
Lead Time:-
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