- interaction： 炎症介质协调宿主对急性细菌感染的免疫和代谢反应，并介导导致脓毒性休克的事件。肿瘤坏死因子(TNF)长期以来被认为是内毒素作用的最接近介质之一。最近的研究已将过氧化物酶体增殖物激活受体α(PPARα)作为调节免疫反应的潜在靶点。由于PPARα激活剂(降脂药物)正在被大量老年患者处方，确定这些药物对宿主对急性炎症反应的影响非常重要。因此，我们研究了PPARα激活剂在内毒素血症小鼠模型中对TNF表达调节的作用。用...处理的CD-1小鼠
- Human toxicity extract： /替代和体外测试/ 过氧化物酶体增殖物激活受体α(PPARα)激动剂在眼炎症中的研究尚未充分。本研究的目的是确定WY-14 643(一种选择性PPARα激动剂)对人眼细胞中炎症细胞因子释放的影响。用1至10 ng/mL白细胞介素1β(IL-1β)刺激原代人角膜上皮细胞、角膜细胞和视网膜内皮细胞，导致多种炎症细胞因子(包括IL-6、IL-8和肿瘤坏死因子α(TNF-α))显著增加；地塞米松能够显著抑制这些效应。然而，WY-14 643未能有效阻断IL-1β诱导的眼细胞细胞因子释放；相反，显著的...
- non-human toxicity value： LD50 小鼠口服 1600 mg/kg
- Hazard categories and classifications： Carc. 1B (100%)
- Antidote and first aid： /SRP:/ 高级治疗：对于意识不清、严重肺水肿或严重呼吸窘迫的患者，考虑经口或经鼻气管插管进行气道控制。使用气囊面罩装置进行正压通气技术可能有益。考虑对肺水肿进行药物治疗...。对于严重支气管痉挛，考虑给予β激动剂如沙丁胺醇...。监测心律并根据需要治疗心律失常...。开始静脉注射D5W /SRP: "保持通畅"，最小流速/。如果出现低血容量迹象，使用0.9%生理盐水(NS)或乳酸盐林格氏液。对于伴有低血容量体征的低血压，谨慎给予液体。注意液体过载的迹象...。用地西泮或劳拉西泮治疗癫痫...。使用...
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Research chemical ≥98. 0%; 100mg
Research chemical ≥98. 0%; 100mg; supplied for laboratory research, analysis, inspection, and scientific procurement use; specifications: ≥98. 0%; 100mg.
