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Product introduction
替莫唑胺是一种咪唑四嗪,是3,4-二氢咪唑[5,1-d][1,2,3,5]四嗪,分别在3、4和8位被甲基、氧代和甲酰胺基取代。它是MTIC(5-(3-甲基三氮烯-1-基)-1H-咪唑-4-甲酰胺)的前药,由替莫唑胺在体内自发水解形成,用作口服烷化剂,治疗新诊断的恶性多形性胶质母细胞瘤(与放射治疗联合使用)和恶性黑色素瘤。它具有烷化剂、抗肿瘤药物和前药的作用。它是一种单羧酸酰胺、咪唑四嗪和三氮烯衍生物。
Chinese name
替莫唑胺, DNA 抑制剂
English name
3-methyl-4-oxoimidazo[5,1-d][1,2,3,5]tetrazine-8-carboxamide
Chinese alias
替莫唑胺 | 3,4-二氢-3-甲基-4-氧代咪唑并[5,1-d]-1,2,3,5-四嗪-8-甲酰胺 | 8-氨甲酰-3-甲基咪唑[5,1-d]-1,2,3,5-四嗪-4(3H)-酮, | 3-甲基-4-氧代-3,4-二氢咪唑并[5,1-d][1,2,3,5]四嗪-8-甲酰胺 | 4-甲基-5-氧代-2,3,4,6,8-五氮杂双环[4.3.0]壬基-2,7,9-三烯-9-甲酰胺
English alias
4-methyl-5-oxo-2,3,4,6,8-pentazabicyclo[4.3.0]nona-2,7,9-triene-9-carboxamide | CCRG 81045 | NSC 362856 | TMZ | 3,4-Dihydro-3-methyl-4-oxoimidazo[5,1-d][1,2,3,5]tetrazine-8-carboxamide | 8-Carbamoyl-3-methylimidazo[5,1-d]-1,2,3,5-tetrazin-4(3H)-one | TZM
CAS number
85622-93-1
molecular formula
C6H6N6O2
molecular weight
194.15
Exact mass
-
PSA
106
Logp
-1.1
Safety
  • Hepatotoxicity: 可能性评分:B(极有可能但罕见的导致明显肝损伤和乙型肝炎再激活的原因)。
  • Hazard categories and classifications: STOT RE 1 (56.8%)
  • Drug Induced Liver Injury: 参考文献:DOI:10.1016/j.drudis.2019.09.022
  • Effects During Pregnancy and Lactation: 一名在妊娠中期被诊断为霍奇金淋巴瘤的妇女在妊娠晚期接受了3轮化疗,并在产后4周恢复化疗。在重新开始化疗后的16周内,在化疗前15至30分钟和化疗后收集乳汁样本。方案包括多柔比星40 mg、博来霉素16单位、长春碱9.6 mg和达卡巴嗪600 mg,所有药物在2小时内给予,每2周一次。她乳汁中的微生物群和代谢谱与8名未接受化疗的健康女性进行了比较。患者乳汁中的微生物群与健康女性明显不同,不动杆菌属、黄单胞菌科和窄食单胞菌属增加,而...
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Research chemical ≥98. 0%; 100mg

Research chemical ≥98. 0%; 100mg; supplied for laboratory research, analysis, inspection, and scientific procurement use; specifications: ≥98. 0%; 100mg.

item number:713655-100mg
Product model:100mg
level: ≥98. 0%; 100mg
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