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Product introduction

Deguelin 是一种天然存在的鱼藤酮类化合物，通过阻止多种途径 (如 PI3K-Akt，IKK-NF-κB 和 MAPK-mTOR-survivin 等) 充当化学预防剂。Deguelin 与 Hsp90 的结合导致许多致癌蛋白 (包括 MEK1/2，Akt，HIF1α，COX-2 和 NF-κB) 的表达降低。 Deguelin，一种从植物中分离出来的天然产物，是PI3K/Akt的抑制剂。最大吸收波长 314(MeOH) nm Application (−)-Deguelin has been used as: a nicotinamide adenine dinucleotide hydrogen (NADH) dehydrogenase (Complex I) inhibitor to study its effects on mitochondrial respiratory inhibition in human hepatocarcinoma cells (HepG2) and human renal proximal tubule epithelial cells (RPTECs) an antiviral compound to study inhibitory effects on human cytomegalovirus (HCMV)-infected human foreskin fibroblast (HFF) cells an analytical standard in high-performance liquid chromatography (HPLC)

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Chinese name

(-)-鱼藤素

English name

Deguelin

Chinese alias

(7aS,13aS)-9,10-二甲氧基-3,3-二甲基-13,13a-二氢-3H-吡喃并[2,3-c:6,5-f']二苯并吡喃-7(7aH)-酮 | (7aS,13aS)-13,13a-二氢-9,10-二甲氧基-3,3-二甲基-3H-双[1]苯并吡喃并[3,4-b:6',5'-e]吡喃-7(7aH)-酮 | 鱼藤素

English alias

CAS number

522-17-8

molecular formula

C23H22O6

molecular weight

394.42 g/mol

Exact mass

10mM in DMSO

PSA

63.200 Å²

Logp

3.700

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