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Product introduction

Amitriptyline-d6 (hydrochloride) 是 Amitriptyline hydrochloride 的氘代物。Amitriptyline hydrochloride 是一种血清素再摄取转运体 (SERT) 和去甲肾上腺素再摄取转运体 (NET) 抑制剂，对人的 SERT 和 NET 作用的 Ki 值分别为 3.45 nM 和 13.3 nM。Amitriptyline hydrochloride 还与多巴胺再摄取转运体 (DAT) 结合，其 Ki 为 2.58 μM。Amitriptyline hydrochloride 也抑制肾上腺素能受体 (adrenergic receptor)、毒蕈碱受体 (muscarinic receptor )、组胺受体 (histamine receptor )、5-羟色胺受体 (5-HT receptor)。Amitriptyline hydrochloride 是一种具有强神经营养活性的 TrkA 和 TrkA 受体激动剂。Amitriptyline hydrochloride 具有抗抑郁作用。 Amitriptyline-d6 (hydrochloride) is the deuterium labeled Amitriptyline hydrochloride. Amitriptyline hydrochloride is an inhibitor of serotonin reuptake transporter (SERT) and noradrenaline reuptake transporter (NET), with Kis of 3.45 nM and 13.3 nM for human SERT and NET, respectively. Amitriptyline hydrochloride also weakly binds to dopamine reuptake transporter (DAT) with a Ki of 2.58 μM. Amitriptyline hydrochloride also inhibits adrenergic, muscarinic, histamine and 5-HT receptors. Amitriptyline hydrochloride is a TrkA and TrkB receptors agonist with potent neurotrophic activity. Amitriptyline hydrochloride has antidepressant activity

Specs ⸢ View details ⸥

Chinese name

盐酸阿米替林-d6

English name

Amitriptyline-d6 Hydrochloride

Chinese alias

English alias

3-(5,6-dihydrodibenzo[1,2-a:2',1'-d][7]annulen-11-ylidene)-N,N-bis(trideuteriomethyl)propan-1-amine;hydrochloride | 3-(10,11-Dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)-N,N-dimethyl-1-propanamine-d6 Hydrochloride

CAS number

203645-63-0

molecular formula

C20H18D6ClN

molecular weight

319.90 g/mol

Exact mass

≥99 atom% D,≥98%

PSA

Logp

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