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Product introduction

N-去甲基氯氮平-d8是N-去甲基氯氮平的氘代物。N-去甲基氯氮平是非典型抗精神病有效剂 Clozapine 的主要活性代谢产物。N-去甲基氯氮平是一种有效的、变构的部分 M1 受体激动剂 (EC50=115 nM)，能通过 M1 受体激活增强海马 N-methyl-d-aspartate (NMDA) 受体电流。N-去甲基氯氮平也是 δ-opioid 激动剂。 N-Desmethylclozapine-d8 is the deuterium labeled N-Desmethylclozapine. N-Desmethylclozapine is a major active metabolite of the atypical antipsychotic agent Clozapine. N-Desmethylclozapine is a potent, allosteric and partial M1 receptors agonist (EC50=115 nM) and is able to potentiate hippocampal N-methyl-d-aspartate (NMDA) receptor currents through M1 receptor activation. N-Desmethylclozapine is also a δ-opioid agonist.

Specs ⸢ View details ⸥

Chinese name

N-去甲基氯氮平-d8

English name

N-Desmethyl Clozapine-d8

Chinese alias

8-氯-11-(哌嗪-1-基-2,2,3,3,5,5,6,6-d8)-5H-二苯并[b,e][1,4]二氮卓

English alias

CAS number

1189888-77-4

molecular formula

C17H9D8ClN4

molecular weight

320.85 g/mol

Exact mass

≥98%(CP),≥98 atom% D

PSA

Logp

Technical Documents

1189888-77-4 | N-Desmethylclozapine-D8.pdf
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