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Product introduction

Olaparib (AZD2281, Ku-0059436)是一种选择性的PARP1/2抑制剂，IC50为5 nM/1 nM，比对Tankyrase-1的作用强300倍。A potent inhibitor of PARP Olaparib (AZD2281, KU0059436) is a selective inhibitor of PARP1/2 with IC50 of 5 nM/1 nM, 300-times less effective against tankyrase-1. A potent inhibitor of PARP

Specs ⸢ View details ⸥

Chinese name

奥拉帕尼 (AZD2281, Ku-0059436), PARP 1、2 和 3 抑制剂

English name

Olaparib (AZD2281, Ku-0059436)

Chinese alias

奥拉帕尼 | 奥拉帕利 | 4-[3-[4-(环丙烷羰基)哌嗪-1-羰基]-4-氟苄基]酞嗪-1(2H)-酮

English alias

KU-0059436 | KU0059436 | KU-0059436 | 4-({3-[(4-cyclopropanecarbonylpiperazin-1-yl)carbonyl]-4-fluorophenyl}methyl)-1,2-dihydrophthalazin-1-one | 4-[3-(4-Cyclopropanecarbonyl-piperazine-1-carbonyl)-4-fluoro-benzyl]-2H-phthalazin-1-one | Lynparza | DTXSID6

CAS number

763113-22-0

molecular formula

C24H23FN4O3

molecular weight

434.46 g/mol

Exact mass

PSA

82.100 Å²

Logp

1.9

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