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棉酚是一种从木槿中分离出来的消炎性五羟基黄酮葡萄糖苷，可用作治疗糖尿病、黄疸和炎症的草药。棉酚可有效抑制人类癌细胞的增殖，包括黑色素瘤和神经胶质瘤细胞。棉酚蛋白能够直接结合并抑制BRAFV600E和CDK4激酶，并调节U251胶质瘤细胞中的Chk1和Cdc25C Gossypin is an anti-inflammatory pentahydroxyflavone glucoside isolated from Hibiscus vitifolius that is used as an herbal remedy for diabetes, jaundice, and inflammation. Gossypin potently inhibits human cancer cell proliferation, including melanoma and glioma cells. Gossypin directly binds and inhibits BRAFV600E and CDK4 kinases, and also regulates Chk1 and Cdc25C in U251 glioma cells.

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Chinese name

棉酚

English name

Gossypin

Chinese alias

2-(3,4-二羟基苯)-8-(β-D-吡喃葡萄糖基氧基)-3,5,7-三羟基-4H-1-苯并吡喃-4-酮 | 3,3′,4′,5,7,8-六羟基黄酮8-葡萄糖苷 | 棉花皮素-8-葡萄糖甙 | 棉纤维素

English alias

Gossypetin 8-glucoside | 3,3′,4′,5,7,8-Hexahydroxyflavone 8-glucosid | 2-(3,4-Dihydroxyphenyl)-8-(β-D-glucopyranosyloxy)-3,5,7-trihydroxy- 4H-1-benzopyran-4-one

CAS number

652-78-8

molecular formula

C21H20O13

molecular weight

480.38 g/mol

Exact mass

PSA

227.000 Å²

Logp

Technical Documents

652-78-8 | Gossypin.pdf
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