- Hazard summary： 普鲁卡因过敏曾是牙医常见的皮肤致敏因素。普鲁卡因、苯佐卡因和丁卡因之间存在交叉反应，但与目前使用的利多卡因和其他酰胺类局部麻醉剂没有交叉反应。[Kanerva, p. 434]
- Harmful effect： 对丁卡因可能发生过敏反应。虽然局部麻醉剂过敏罕见，但在氨基酯类中比氨基酰胺类更常见。这种反应主要归因于对氨基苯甲酸(PABA)。除此之外，有必要检查药物标签中是否有任何防腐剂的添加，特别是甲基对羟基苯甲酸，它会代谢为PABA。
- Toxicity summary： 虽然目前没有特卡因毒性的直接解毒剂或治疗方法，但建议立即开始脂质拯救治疗。静脉内注射浓缩脂质理论上可以作为自由循环局部麻醉剂的储液器，使药物能够从全身循环中快速清除。应立即以1.5 mL/kg的剂量开始20%脂肪乳，随后以0.25 mL/kg/min的速度输注。如果患者持续存在血流动力学障碍或心律失常，可重复推注剂量，并增加输注速度。
- ecotoxicity value： 美国农业部APHIS化学影响: collection=usda_chemeffect&query_type=synonym&query='^94-24-6$'
- Other safety information： 化学品评估：IMAP评估 - 4-(丁基氨基)苯甲酸, 2-(二甲基氨基)乙酯：人类健康I级评估
- Hazard categories and classifications： Carc. 2 (93%)
- Drug Induced Liver Injury： 参考文献：DOI:10.1016/j.drudis.2019.09.022
- Effects During Pregnancy and Lactation： ◉ 对哺乳和母乳的影响
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Research chemical ≥98. 0%; 100mg
Research chemical ≥98. 0%; 100mg; supplied for laboratory research, analysis, inspection, and scientific procurement use; specifications: ≥98. 0%; 100mg.
