Share to
Overview
Specs
Safety
Technical Documents
Related
Articles
reviews
Consult
returns
Product introduction
物理描述 | 甲苯磺丁脲呈白色至淡白色结晶性粉末。无味或略有气味。(NTP,1992)
Chinese name
托拉唑胺, 磺酰脲受体 1、Kir6.2 阻断剂
English name
1-(azepan-1-yl)-3-(4-methylphenyl)sulfonylurea
Chinese alias
妥拉磺脲 | N-(氮杂卓-1-基氨基甲酰基)-4-甲基苯磺酰胺
English alias
1-(azepan-1-yl)-3-(4-methylbenzenesulfonyl)urea | 1-(4-Methylphenylsulfonyl)-3-(hexahydro-1H-azepin-1-yl)urea | CBiol_001918 | TOLAZAMIDE [MART.] | KBioSS_000225 | Oprea1_061180 | Prestwick1_000554 | TOLAZAMIDE [USP MONOGRAPH] | AI3-50826 | KBio2_002793 |
CAS number
1156-19-0
molecular formula
C14H21N3O3S
molecular weight
311.40
Exact mass
-
PSA
86.9
Logp
1.5
Safety
  • Health hazard: 急/慢性危害:加热分解时,该化合物 emits 氮氧化物和硫氧化物的剧毒烟雾。(NTP, 1992)
  • reactive group: 磺酸盐、膦酸盐和硫代膦酸盐,有机
  • Disposal method: SRP:在审查时,土地处理或填埋(卫生填埋)处置实践的标准正在重大修订中。在实施废物残渣(包括废物污泥)的土地处置之前,咨询环境监管机构以获取可接受的处置实践指导。
  • First aid measures: 食入:不要催吐。如果受害者意识清醒且没有抽搐,给予1-2杯水稀释化学物质,并立即呼叫医院或中毒控制中心。如果医生建议,准备将受害者送往医院。如果受害者抽搐或昏迷,不要经口给予任何东西,确保受害者的气道通畅,让受害者侧卧,头部低于身体。不要催吐。立即将受害者送往医院。(NTP, 1992)
  • exposure pathway: 从胃肠道迅速且良好吸收。
  • Toxicity summary: 磺脲类药物可能结合到胰腺细胞表面的ATP敏感性钾通道受体上,减少钾电导并导致膜去极化。去极化通过电压敏感性钙通道刺激钙离子内流,提高细胞内钙离子浓度,从而诱导胰岛素的分泌或胞吐作用。
  • fire hazard: 该化学品的闪点数据不可用;但可能是可燃的。(NTP, 1992)
  • fire fighting: 涉及此材料的火灾可以用干化学灭火器、二氧化碳或哈龙灭火器控制。(NTP, 1992)
  • Special Reports: DHEW/NCI;甲苯磺丁脲致癌性生物测定(1978)技术报告系列第51号 DHEW出版物号(NIH)78-1756
  • Symptoms and Signs: 磺酰�类药物过量可导致低血糖。严重低血糖反应伴有昏迷、癫痫或其他神经系统损害很少发生,但构成需要立即住院的医疗紧急情况。
  • Human toxicity extract: 昏迷或精神状态改变通常是大多数(90%)摄入过量磺酰脲类药物患者最重要的表现症状.../磺酰脲/
  • Other safety information: 化学品评估:IMAP评估 - 苯磺酰胺,N-[[(六氢-1H-氮杂卓-1-基)氨基]羰基]-4-甲基-:环境I级评估
  • Air and water reaction: 该化学品可能对长期暴露于空气中敏感。不溶于水。
  • Hazard categories and classifications: 特定靶器官毒性-单次接触1级(50%)
  • Non-fire leakage response: 储存注意事项:您应将此材料保存在密闭容器中,置于惰性气氛下,并在冷藏温度下储存。(NTP, 1992)
  • Personal protective equipment (PPE): 推荐呼吸器:在称量和稀释纯测试化学品时,佩戴NIOSH批准的半面罩呼吸器,配备有机蒸气/酸性气体 cartridges(专门用于有机蒸气、HCl、酸性气体和SO2)和粉尘/雾过滤器。(NTP,1992)
  • Carcinogen Classification: 对人类无致癌性迹象(未被IARC列出)。
  • Drug Induced Liver Injury: 参考文献:DOI:10.1016/j.drudis.2019.09.022
  • Effects During Pregnancy and Lactation: ◉ 对哺乳和母乳的影响
Related
upstream information
Manufacturing method:
1-氨基己亚甲基亚胺 (CID:22198)
Articles
「No related articles yet」
user reviews
Loading...
Consultation

Warm reminder:

Because the manufacturer may temporarily adjust product specifications, prices, inventory, parameters and other information without notice, and there are differences in each user's consultation time and procurement needs, the platform reply content is only of reference value within a certain period. Sorry for the inconvenience caused to you, and thank you for your understanding and support! Please consult the online customer service for the latest details. Everything is subject to the real-time reply of the customer service.!

After Sales Services

Please check the quantity, appearance and product information in time when you receive the goods. In case of damage, wrong delivery, abnormal quality and other problems, please feel free to contact us.

Service Hotline:400-6226-992 ,We will handle it for you as soon as possible, thank you for your support and trust.!

Research chemical 50mg

Research chemical 50mg; supplied for laboratory research, analysis, inspection, and scientific procurement use; specifications: 50mg.

item number:76984-50mg
Product model:50mg
level: 50mg
Lead Time:-
sold 978 Items
Ask Solution engineer
Qty

Recommended for you