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Product introduction
非洛地平是4-(2,3-二氯苯基)-2,6-二甲基-1,4-二氢吡啶-3,5-二甲酸的混合(甲基、乙基)二酯。作为钙通道阻滞剂,它通过作用于小动脉阻力血管平滑肌的高度选择性作用,降低外周血管阻力来降低血压。用于治疗高血压和心绞痛。它具有血管扩张剂、降压药、抗心律失常药物和钙通道阻滞剂的作用。它是一种二氯苯、乙酯、甲酯和二氢吡啶。
Chinese name
非洛地平, CFTR 激活剂
English name
5-O-ethyl 3-O-methyl 4-(2,3-dichlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate
Chinese alias
乙基甲基4-(2,3-二氯苯基)-1,4-二氢-2,6-二甲基-3,5-吡啶二羧酸
English alias
BPBio1_000678 | Felodipine (dl form) | FELODIPINE (EP MONOGRAPH) | FELODIPINE [MI] | Plendil;Renedil | Prevex | SMR000058204 | C18H19Cl2NO4 | Felodipine,(S) | Logimax | FELODIPINE (USP IMPURITY) | BIDD:GT0733 | Felodipine, solid | Modip | Opera_ID_1873 |
CAS number
72509-76-3
molecular formula
C18H19Cl2NO4
molecular weight
384.2
Exact mass
-
PSA
64.6
Logp
3.9
Safety
  • Harmful effect: * 钙通道阻滞剂和他汀类药物常被用于有心血管风险因素的患者。在一项研究中,由于CYP3A4代谢的他汀类药物与抑制CYP3A4的钙通道阻滞剂(如非洛地平)之间的相互作用,导致急性肾损伤、高钾血症、急性心肌梗死和急性缺血性中风增加。
  • Toxicity summary: 对于严重过量的患者,应静脉注射阿托品治疗心动过缓。应定期监测生命体征、血清电解质(特别是钾)、血糖、尿量和心电图。高胰岛素-正常血糖疗法也是治疗钙通道阻滞剂过量的既定疗法。该疗法有助于从外周组织动员葡萄糖,作为心肌的替代能量来源。
  • Hazard categories and classifications: 水生慢性1级(15.3%)
  • Drug Induced Liver Injury: 参考文献:DOI:10.1016/j.drudis.2019.09.022
  • Effects During Pregnancy and Lactation: ◉ 对哺乳和母乳的影响
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Research chemical 1mL

Research chemical 1mL; supplied for laboratory research, analysis, inspection, and scientific procurement use; specifications: 1mL.

item number:92030a
Product model:1mL
level: 1mL
Lead Time:-
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