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Product introduction
物理描述 | 晶体;白色粉末。(NTP, 1992)
Chinese name
氯噻嗪, Na-Cl 合酶抑制剂
English name
6-chloro-1,1-dioxo-4H-1lambda6,2,4-benzothiadiazine-7-sulfonamide
Chinese alias
克尿塞 | 克尿噻 | 氯消疾 | 氯消痰
English alias
6-chloro-1,1-dioxo-2H-1$l^{6},2,4-benzothiadiazine-7-sulfonamide | Spectrum_000134 | 6-chloro-4H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide | CHLOROTHIAZIDE [VANDF] | Lopac0_000254 | Saluretil | CHLOROTHIAZIDE [USP MONOGRAPH] | Alurene | Chlorothiaz
CAS number
58-94-6
molecular formula
C7H6ClN3O4S2
molecular weight
295.7
Exact mass
-
PSA
135
Logp
-0.2
Safety
  • Health hazard: 急性/慢性危害:该化合物可能引起皮肤和粘膜刺激。加热分解时会产生剧毒烟雾。(NTP,1992)
  • reactive group: 芳基卤化物
  • Disposal method: SRP:在审查时,土地处理或填埋(卫生填埋)处置实践的标准正在重大修订中。在实施废物残渣(包括废物污泥)的土地处置之前,咨询环境监管机构以获取可接受的处置实践指导。
  • First aid measures: 食入:不要催吐。如果受害者意识清醒且没有抽搐,给予1-2杯水稀释化学物质,并立即呼叫医院或中毒控制中心。如果医生建议,准备将受害者送往医院。如果受害者抽搐或昏迷,不要经口给予任何东西,确保受害者的气道通畅,让受害者侧卧,头部低于身体。不要催吐。立即将受害者送往医院。(NTP, 1992)
  • fire hazard: 该化学品的闪点数据不可用;但可能是可燃的。(NTP, 1992)
  • fire fighting: 涉及此材料的火灾可以用二氧化碳、干化学或哈龙灭火器控制。(NTP, 1992)
  • reactivity profile: 碱性水溶液在静置或加热时会分解(NTP,1992)。
  • Human toxicity extract: 可能抑制泌乳,但与母乳喂养兼容/SRP:/。/噻嗪类利尿剂,来自表格/
  • Other safety information: 化学评估:IMAP评估 - 2H-1,2,4-苯并噻二嗪-7-磺酰胺,6-氯-,1,1-二氧化物:环境I级评估
  • Air and water reaction: 不溶于水.
  • Milk Concentrations: 氯噻嗪以低浓度分泌到母乳中。
  • Hazard categories and classifications: 呼吸致敏物 1 (100%)
  • Non-human toxic extract: 一些狗因碳酸氢盐潴留和碱中毒而发生低氯血症。
  • Non-fire leakage response: 储存注意事项:您应将此材料存放在冰箱中。(NTP, 1992)
  • Personal protective equipment (PPE): 推荐呼吸器:在称量和稀释纯测试化学品时,佩戴NIOSH批准的半面罩呼吸器,配备有机蒸气/酸性气体 cartridges(专门用于有机蒸气、HCl、酸性气体和SO2)和粉尘/雾过滤器。(NTP,1992)
  • Antidote and first aid: 噻嗪类利尿剂过量应立即进行胃排空,然后进行支持性对症治疗,并监测血清电解质浓度和肾功能。/噻嗪类利尿剂/
  • Drug Induced Liver Injury: 参考文献:DOI:10.1016/j.drudis.2019.09.022
  • Effects During Pregnancy and Lactation: 截至修订日期,未找到关于氯噻嗪的相关已发表信息。噻嗪类和噻嗪样利尿剂、限制液体摄入和乳房压迫已被用于抑制产后泌乳。利尿剂对这些有效抑制泌乳措施的附加贡献尚未研究。关于利尿剂对已建立的持续泌乳的影响没有数据。
Technical Documents
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Related
upstream information
Manufacturing method:
3-氯苯胺 (CID:7932); 氯磺酸 (CID:24638); 氨 (CID:222); 甲酸 (CID:284) <<<45>>氯苯甘氨酸氨基甲酸酯是氯苯甘氨酸伯羟基的氨基甲酸酯。一种中枢性作用骨骼肌松弛剂,用于疼痛性肌肉痉挛的症状治疗。它具有肌肉松弛剂的作用。它是一种氨基甲酸酯、二级醇和一氯苯的成员。它在功能上与氨基甲酸和氯苯甘氨酸相关。
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Research chemical 1mL

Research chemical 1mL; supplied for laboratory research, analysis, inspection, and scientific procurement use; specifications: 1mL.

item number:92312a
Product model:1mL
level: 1mL
Lead Time:-
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