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Product introduction

Dutasteride is a 5-α-reductase inhibitor that inhibits the conversion of testosterone into dihydrotestosterone (DHT). Dutasteride inhibits both isoforms of 5-α reductase (5 α-Reductase 1/5aR1 and 5 α-Reductase 2/5aR2) to a similar extent (IC50 6nmol/l and 7 nmol/l, respectively), while finasteride only inhibits Type II. Dutasteride competed for binding the LNCaP cell AR with an IC50 approximately 1.5 μM. Dutasteride is a dual 5-α reductase inhibitor that inhibits conversion of testosterone to dihydrotestosterone (DHT).

Specs ⸢ View details ⸥

Chinese name

度他雄胺 (GG745), 类固醇 5-α-还原酶抑制剂

English name

Dutasteride (GG745)

Chinese alias

度他雄胺 | (5α,17β)-N-[2,5-双(三氟甲基)苯基]-3-氧代-4-氮杂雄-1-烯-17-甲酰胺

English alias

(5.alpha.,5 bis(trifluoromethyl)phenyl}-3-oxo-4-azaandrost-1-ene-17-carboxamide;dutasteride;Avodart; | DUTASTERIDE (EP MONOGRAPH) | DUTASTERIDE [ORANGE BOOK] | GG 745 | JALYN COMPONENT DUTASTERIDE | AKOS001174240 | BRD-K30373883-001-02-8 | CHEBI:521033 |

CAS number

164656-23-9

molecular formula

C27H30F6N2O2

molecular weight

528.53 g/mol

Exact mass

PSA

58.200 Å²

Logp

5.4

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